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A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain

Information source: Cukurova University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Chronic Pain

Intervention: Morphine (Drug); Morphine plus dexmedetomidine (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Cukurova University

Official(s) and/or principal investigator(s):
Selcuk Gök, M.D, Principal Investigator, Affiliation: Cukurova University

Overall contact:
Ersel Gulec, M.D, Phone: +903223386060, Ext: 3262, Email: gulecersel@yahoo.com


The purpose of this study is to determine whether dexmedetomidine added to morphine is effective in the treatment of chronic cancer pain.

Clinical Details

Official title: A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Morphine consumption (mg)

Secondary outcome: Pain score

Detailed description: We conduct the study in Cukurova University Faculty of Medicine Research Hospital after obtaining ethics committee approval and patient's informed consent. Patients with cancer pain are allocated into two group to receive Patient Controlled Analgesia with morphine or morphine plus dexmedetomidine.


Minimum age: 20 Years. Maximum age: 80 Years. Gender(s): Both.


Inclusion Criteria:

- patients with chronic cancer pain

- between 20-80 years old age

Exclusion Criteria:

- the presence of severe systemic disease(cardiac, pulmonary, hepatic or renal)

- psychiatric or neurologic disease

- unable to communicate verbally

- nausea and vomiting

- patient's refusal

Locations and Contacts

Ersel Gulec, M.D, Phone: +903223386060, Ext: 3262, Email: gulecersel@yahoo.com

Cukurova University Faculty of Medicine Research Hospital, Adana 01130, Turkey; Recruiting
Ersel Gulec, M.D., Phone: +903223386060, Ext: 3289, Email: gulecersel@yahoo.com
Selçuk Gök, M.D., Principal Investigator
Ersel Gulec, M.D., Sub-Investigator
Hayri Özbek, M.D., Sub-Investigator
Additional Information

Related publications:

Blaudszun G, Lysakowski C, Elia N, Tramèr MR. Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. Anesthesiology. 2012 Jun;116(6):1312-22. doi: 10.1097/ALN.0b013e31825681cb. Review.

Starting date: November 2014
Last updated: November 10, 2014

Page last updated: August 23, 2015

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