Comparing the Analgesic Effect of Intravenous Acetaminophen and Morphine on Patients With Renal Colic Pain Reffering to the Emergency Department: A Randomized Controlled Trial
Information source: Isfahan University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Renal Colic
Intervention: Acetaminophen (Drug); Morphine (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: Seyed Mehdi Pourafzali
Summary
Kidney stone is one of the most common diseases in every human society and also Iran. What
is normally used to treat renal colic pain is Intravenous Opioid with a variety of side
effects including hypotension, respiratory depression and apnea, nausea and vomiting.
Regarding less complications of Intravenous Acetaminophen, we aimed to compare it with
Intravenous Morphine in management of renal colic pain.
Clinical Details
Official title: Comparing the Effect of Intravenous Morphine and Injectable Acetaminophen on Renal Colic Patients Presenting to the Emergency Department: A Randomized Controlled Trial
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
Primary outcome: Pain
Detailed description:
Kidney stone is one of the common diseases of human society which is demonstrated in the
form of renal colic. Evidences indicate that renal colic is one of the mot painful
conditions that require urgent pain relief treatment.
Patients suffering from renal colic do not usually recover from pain by using oral pain
killers or rectal suppositories. Hence, a considerable percentage of these patients are
admitted to the emergency department. A bothering and sharp pain is the most common
characteristics of renal colic pain that wakes the patient up in the middle of the night. To
achieve more relief, patients somehow take unusual positions such as squatting.
What are normally used as pain relievers in emergency department are Non-steroidal
anti-inflammatory drugs (NSAIDs) and intravenous Opioids. However, both of these classes of
drugs have many side effects.
Another point in this regard which is worthy to be mentioned is that some patients with
renal colic complaint are drug addicted, so we have to administer higher dosage of analgesic
drugs. According to the statistics provided by the US National Library website, the
prevalence of kidney stones around the world in 2005 has been averagely around 140. 1% which
is considerable. This issue suggests more attention to the field of prevention and
treatment.
According to the statistics of kidney stones incidence in Iran, 2. 4 out of every 1000 people
suffer from this pathologic condition whereas it differs from 0. 5 to 2 in every 1000 ones in
other countries.
Intravenous Acetaminophen has been imported to our country and introduced with the brand of
Apotel. In this regard, we decided to compare the effect of Intravenous Acetaminophen and
Morphine on renal colic pain.
Eligibility
Minimum age: 15 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- aged 15 to 80 years
- weight of 60 to 80 kilograms
- known case of renal colic based on physical examination and Ultrasonography
Exclusion Criteria:
- Addiction
- allergic to Opioids and Acetaminophen
- receiving any types of analgesic drugs within previous 6 hours
- known cases of Kidney transplantation
- Patients with known heart failure
- Patients with known Liver failure
- Patients with known Respiratory failure
- Patients with known Renal failure
- cases of Blindness and physical disabilities not able to communicate
Locations and Contacts
Additional Information
Starting date: July 2012
Last updated: July 20, 2013
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