Naltrexone and Memantine Effects on Alcohol Drinking Behaviors
Information source: Yale University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Alcohol Drinking
Intervention: Naltrexone and memantine (Drug); Naltrexone and Placebo (Drug)
Phase: Phase 2
Status: Recruiting
Sponsored by: Yale University Official(s) and/or principal investigator(s): Suchitra Krishnan-Sarin, Ph.D., Principal Investigator, Affiliation: Yale University
Overall contact: Nicholas Franco, B.A., Phone: 203 974-7679, Email: nicholas.franco@yale.edu
Summary
The purpose of this study is to evaluate the combined effects of the study medications
naltrexone and memantine on alcohol drinking behaviors. Participants will be randomized to
receive a combination of these medications over a one week period and then participate in a
laboratory session. During this session, participants are given an initial drink of alcohol
followed by the choice to drink up to 12 more drinks over a three-hour period. These
medications are hypothesized to reduce craving and number of drinks consumed prior to and
after exposure to the initial drink of alcohol and during the three hour drinking period.
Clinical Details
Official title: Glutamate-opioid Interactions in Alcohol Drinking Behaviors
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)
Primary outcome: number of drinks consumed
Secondary outcome: Stimulation and sedation responses to alcohol
Eligibility
Minimum age: 21 Years.
Maximum age: 55 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Ages 21-55
- Able to read English at 6th grade level or higher and to complete study evaluations
- Regular alcohol drinker
Exclusion Criteria:
- Individuals who are seeking alcohol treatment
- Medical conditions that would contraindicate the use of study medication
- Regular use of other substances
Locations and Contacts
Nicholas Franco, B.A., Phone: 203 974-7679, Email: nicholas.franco@yale.edu
Sac, Cmhc, New Haven, Connecticut 06519, United States; Recruiting
Additional Information
Starting date: January 2012
Last updated: January 20, 2015
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