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Naltrexone and Memantine Effects on Alcohol Drinking Behaviors

Information source: Yale University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Alcohol Drinking

Intervention: Naltrexone and memantine (Drug); Naltrexone and Placebo (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: Yale University

Official(s) and/or principal investigator(s):
Suchitra Krishnan-Sarin, Ph.D., Principal Investigator, Affiliation: Yale University

Overall contact:
Nicholas Franco, B.A., Phone: 203 974-7679, Email: nicholas.franco@yale.edu

Summary

The purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors. Participants will be randomized to receive a combination of these medications over a one week period and then participate in a laboratory session. During this session, participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. These medications are hypothesized to reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period.

Clinical Details

Official title: Glutamate-opioid Interactions in Alcohol Drinking Behaviors

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)

Primary outcome: number of drinks consumed

Secondary outcome: Stimulation and sedation responses to alcohol

Eligibility

Minimum age: 21 Years. Maximum age: 55 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Ages 21-55

- Able to read English at 6th grade level or higher and to complete study evaluations

- Regular alcohol drinker

Exclusion Criteria:

- Individuals who are seeking alcohol treatment

- Medical conditions that would contraindicate the use of study medication

- Regular use of other substances

Locations and Contacts

Nicholas Franco, B.A., Phone: 203 974-7679, Email: nicholas.franco@yale.edu

Sac, Cmhc, New Haven, Connecticut 06519, United States; Recruiting
Additional Information

Starting date: January 2012
Last updated: January 20, 2015

Page last updated: August 23, 2015

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