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ROTAHALER Device Optimization Study

Information source: GlaxoSmithKline
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Asthma

Intervention: Fluticasone Propionate / Salmeterol Xinafoate DISKUS (Drug); Fluticasone Propionate / Salmeterol Xinafoate ROTACAP (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: GlaxoSmithKline

Official(s) and/or principal investigator(s):
GSK Clinical Trials, Study Director, Affiliation: GlaxoSmithKline

Summary

This study will compare the pharmacokinetic (PK) of Fluticasone Propionate/Salmeterol combination (FSC) 100/50 micrograms (mcg) delivered via the capsule-based inhaler (Rdpi) relative to FSC 100/50 mcg delivered via the multi-dose dry powder inhaler (Ddpi) to establish whether the Rdpi inhaler has exposure (in terms of fluticasone propionate area under time concentration curve [AUC] and Salmeterol maximum concentration [Cmax]) no greater than 1. 2500 compared to the Ddpi, sufficient to allow progression to Phase 3. This study will enroll 36 healthy adult male and female subjects and each subject will be allocated to one of two sequences and will participate in four treatment periods, receiving each of the treatments twice.

Clinical Details

Official title: An Open-Label, Randomised, Two Treatment, Four-Way Cross-Over (Replicate Design), Two Sequence, Repeat Dose, Single Centre Study in Healthy Volunteers to Compare the Pharmacokinetics of Fluticasone Propionate/Salmeterol (100/50 Mcg) Delivered Via the Low Airflow Resistance ROTAHALER Inhaler Relative to Fluticasone Propionate/Salmeterol (100/50 Mcg) Delivered Via the DISKUS Inhaler

Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Composite of PK parameters of FSC delivered via the Rdpi relative to FSC delivered via the Ddpi

Secondary outcome:

Composite of PK parameters of FSC delivered via the Rdpi relative to FSC delivered via the Ddpi

Number of participants with adverse events (AEs) as measure of safety and tolerability.

Laboratory parameters as a measure of safety and tolerability.

Vital sign measurement as measure of safety and tolerability.

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria

- Males and females aged between 18 and 65 years of age inclusive, at the time of

signing the informed consent.

- Healthy as determined by a responsible and experienced physician, based on a medical

evaluation including medical history, physical examination, laboratory tests and cardiac monitoring. A subject with a clinical abnormality or laboratory parameters which is/are not specifically listed in the inclusion or exclusion criteria, outside the reference range for the population being studied may be included only if the Investigator determines that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures.

- Body mass index within the range 18 to 35 kilograms/meter squared (m^2) (inclusive).

- A female subject is eligible to participate if she is of:

Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy (for this definition, "documented" refers to the outcome of the investigator's/designee's review of the subject's medical history for study eligibility, as obtained via a verbal interview with the subject or from the subject's medical records); or postmenopausal defined as 12 months of spontaneous amenorrhea (in questionable cases a blood sample with simultaneous follicle stimulating hormone > 40 milli international unit/mililiter [mL] and estradiol < 40 picogram/mL [<147 picomoles/liter] is confirmatory. Females on hormone replacement therapy (HRT) and whose menopausal status is in doubt will be required to use one of the contraception methods if they wish to continue their HRT during the study. Otherwise, they must discontinue HRT to allow confirmation of post-menopausal status prior to study enrollment. For most forms of HRT, at least 2 to 4 weeks will elapse between the cessation of therapy and the blood draw; this interval depends on the type and dosage of HRT. Following confirmation of their post-menopausal status, they can resume use of HRT during the study without use of a contraceptive method. Child-bearing potential with negative pregnancy test as determined by serum human chorionic gonadotropin (hCG) test at screening or prior to dosing. Agrees to use one of the contraception methods for an appropriate period of time (as determined by the product label or investigator) prior to the start of dosing to sufficiently minimize the risk of pregnancy at that point. Female subjects must agree to use contraception until 2 days post-last dose. OR has only same-sex partners, when this is her preferred and usual lifestyle.

- Capable of giving written informed consent, which includes compliance with the

requirements and restrictions listed in the consent form.

- Alanine aminotransferase, alkaline phosphatase and bilirubin <= 1. 5xupper limit of

normal (ULN) (isolated bilirubin >1. 5xULN is acceptable if bilirubin is fractionated and direct bilirubin <35 %).

- Based on single or averaged QT interval corrected (QTc) values of triplicate

electrocardiograms (ECGs) obtained over a brief recording period: QT duration corrected for heart rate by Fridericia's formula (QTcF)<450 millisecond (msec), and QT duration corrected for heart rate by Bazett's formula (QTcB)<480 msec in subjects with Bundle Branch Block. Exclusion Criteria

- Current or chronic history of liver disease, or known hepatic or biliary

abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).

- History of regular alcohol consumption within 6 months of the study defined as: An

average weekly intake of >21 units for males or >14 units for females. In Australia one unit (= standard drink) is equivalent to 10 grams of alcohol: 270 mL of full strength beer (4. 8%), 375mL of mid strength beer (3. 5%), 470 mL of light beer (2. 7%), 250 mL pre-mix full strength spirit (5%), 100 mL of wine (13. 5%) and 30 mL of spirit (40%)

- History of sensitivity to any of the study medications, or components thereof or a

history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation.

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody

result within 3 months of screening.

- A positive pre-study drug/alcohol screen.

- A positive test for human immuno virus antibody.

- Pregnant females as determined by positive serum hCG test at screening or prior to

dosing.

- Where participation in the study would result in donation of blood or blood products

in excess of 500 mL within a 56 day period.

- Lactating females.

- The subject has participated in a clinical trial and has received an investigational

product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).

- Exposure to more than four new chemical entities within 12 months prior to the first

dosing day.

Locations and Contacts

GSK Investigational Site, Randwick, New South Wales 2031, Australia
Additional Information

Starting date: August 2013
Last updated: October 17, 2013

Page last updated: August 23, 2015

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