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Ketamine Associated With Morphine PCA After Total Hip Arthroplasty

Information source: Assistance Publique - H˘pitaux de Paris
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Arthroplasty, Replacement, Hip

Intervention: Ketamine-Morphine (Drug); Morphine (Drug); Postoperative PCA of Ketamine and morphine (Drug)

Phase: N/A

Status: Completed

Sponsored by: Assistance Publique - H˘pitaux de Paris

Official(s) and/or principal investigator(s):
Philippe SITBON, MD, Principal Investigator, Affiliation: Assistance Publique - Hôpitaux de Paris Hôpital Bicêtre

Summary

Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect. We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.

Clinical Details

Official title: Impact of the Route of Administration of Ketamine Associated With Morphine PCA on Analgesia After Total Hip Arthroplasty

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome: Morphine consumption in PACU and in hospitalisation room

Secondary outcome:

Postoperative Visual Analogic Score of pain

Postoperative Measure of mechanical hyperalgesia by Von Frey filament device

Postoperative measure Ketamine and Nor-Ketamine blood levels

Detailed description: Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- total hip arthroplasty

Exclusion Criteria:

- pre operative opioid administration

Locations and Contacts

Service d'anesthesie-reanimation - Hôpital Bicêtre, Le Kremlin Bicêtre 94270, France
Additional Information

Starting date: November 2008
Last updated: April 10, 2013

Page last updated: August 23, 2015

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