Unexpected Pharmacokinetics of Vancomycin in Patients With Severe Acute Pancreatitis Compared With Pneumonia
Information source: Ruijin Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Arbitrary Restriction Polymorphism 1
Phase: N/A
Status: Recruiting
Sponsored by: Ruijin Hospital Official(s) and/or principal investigator(s): Wan-Hua Yang, Prof., Study Director, Affiliation: Ruijin Hospital
Overall contact: Juan He, Phone: 86-21-64370045, Ext: 664405, Email: hejuanwin@126.com
Summary
The purpose of this study was to evaluate the influence of severe acute pancreatitis on the
serum level of vancomycin, a glycopeptide antibacterial agent.
Clinical Details
Official title: Unexpected Pharmacokinetics of Vancomycin in Patients With Severe Acute Pancreatitis Compared With Pneumonia
Study design: Observational Model: Case Control, Time Perspective: Retrospective
Primary outcome: vancomycin serum trough concentrations in these patients just prior to the next vancomycin serum trough concentrations was measured
Secondary outcome: the pharmacokinetic parameters was calculated using the Bayesian estimator.
Detailed description:
The purpose of this study was to evaluate the influence of severe acute pancreatitis on the
serum level of vancomycin, a glycopeptide antibacterial agent.
After reviewing more than 6000 clinical charts of patients who received vancomycin therapy
and whose serum vancomycin level was monitored between January 2010 and December 2013, we
identified 212 patients who also had diagnosed as severe acute pancreatitis (SAP group), and
98 patients who also had diagnosed as pneumonia (pneumonia group) at that time. The
fluorescence polarization immunoassay method was used to measure vancomycin serum trough
concentrations in these patients 30 min before the next administration. Using these
measurements, we calculated the pharmacokinetic parameters using the Bayesian estimator.
Eligibility
Minimum age: 18 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- age 18-85years old
- vancomycin use ≥ 3days
Exclusion Criteria:
- age <18years old or >85 years old
- vancomycin use < 3days
Locations and Contacts
Juan He, Phone: 86-21-64370045, Ext: 664405, Email: hejuanwin@126.com
Ruijin Hospital, Shanghai, Shanghai 200025, China; Recruiting He, Phone: 86-21-64370045, Ext: 662618
Additional Information
Starting date: May 2013
Last updated: May 7, 2014
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