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Adjunctive Isradipine for the Treatment of Bipolar Depression

Information source: Massachusetts General Hospital
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Bipolar Disorder

Intervention: Isradipine (Drug); Placebo (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: Massachusetts General Hospital

Official(s) and/or principal investigator(s):
Roy H Perlis, MD, MSc, Principal Investigator, Affiliation: Massachusetts General Hospital

Overall contact:
Roy H Perlis, MD, MSc, Email: rperlis@chgr.mgh.harvard.edu

Summary

This study investigates the medication isradipine, which is currently approved by the FDA to treat high blood pressure, in the treatment of depression in bipolar disorder. Isradipine or placebo (contains no active medication) will be used as an "add-on" to lithium, valproate, and/or atypical antipsychotics for individuals currently experiencing a major depressive episode. Our hypothesis is that isradipine will be superior to placebo in improving depressive symptoms.

Clinical Details

Official title: Adjunctive Isradipine for the Treatment of Bipolar Depression

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Change in MADRS (4 weeks)

Detailed description: Primary Aim: To estimate the antidepressant efficacy of isradipine versus placebo as an adjunct to lithium, valproate, and/or other atypical antipsychotics among individuals with bipolar I disorder in a nonpsychotic major depressive episode. Hypothesis: Isradipine will be superior to placebo in improvement of depressive symptoms assessed by the Montgomery-Asberg Depression Rating Scale (MADRS).

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age 18-65

- written informed consent

- meets DSM-IV criteria (by SCID-I/P) for bipolar I disorder, current episode depressed

- MADRS score of at least 20 (i. e., moderate depression) and no greater than 34 (i. e.,

severe depression) at screen and baseline visit

- YMRS score < 12 at screen and baseline visit

- currently treated with a lithium preparation (carbonate or citrate) at stable dose

for at least 4 wks with level >0. 6 and <1. 0; and/or valproate at stable dose for at least 4 wks at level >60 and <110; and/or other atypical antipsychotic at stable dose for at least 4 weeks (at least minimum FDA-labeled dose)

- Caucasian by self-report - please see discussion below

Exclusion Criteria:

- Psychotic features in the current episode, as assessed by YMRS item #8 > 6 [where

treatment guidelines urge use of antipsychotics that may confound isradipine results]

- felt by the study clinician to require inpatient hospitalization for adequate

management (to include serious suicide or homicide risk, as assessed by evaluating clinician)

- 3 or more failed pharmacologic interventions in the current major depressive episode,

excluding lithium/valproate/other atypical antipsychotic [response rates for these subjects is likely to be extremely low and would require a substantially larger-scale study to identify treatment effects]

- obsessive-compulsive disorder, or any diagnosis of a DSM-IV anxiety disorder where

the anxiety disorder and not bipolar disorder is the primary focus of clinical attention

- current substance use disorder other than nicotine, by SCID-I/P

- a primary clinical diagnosis of a personality disorder, or comorbid diagnosis of

antisocial or borderline personality disorder

- pregnant women or women of child bearing potential who are not using a medically

accepted means of contraception (to include oral contraceptive or implant, condom, diaphragm, spermicide, intrauterine device, tubal ligation, or partner with vasectomy)

- women who are breastfeeding

- other unstable medical illness including cardiovascular, hepatic, renal, respiratory,

endocrine, neurological, or hematological disease, based on review of medical history, physical examination, and screening laboratory tests (this will include any clinical or laboratory evidence of hypothyroidism; if maintained on thyroid medication must be euthyroid for at least 1 month before Visit 1)

- history of hypertension or current treatment for hypertension

- current use of isradipine or history of anaphylactic reaction or intolerance to

isradipine or any component of the preparation

- ECG abnormalities at entry: prolonged QTc or complete or incomplete bundle branch

block

- patients who have taken an investigational psychotropic drug within the last 3 months

- patients receiving other excluded antipsychotics or antidepressants within 2 weeks

prior to study entry

- patients requiring continued treatment with excluded medications (see below).

Excluded medications: antidepressants, antipsychotics, and anticonvulsants (other than valproate), which could influence calcium signaling or impact mood; other calcium channel blockers; any other antihypertensive because of the risk of cause hypotension; any other drug known to interact with isradipine. Benzodiazepines or other sedative-hypnotic agents (e. g., zolpidem) may not be initiated after study entry; subjects requiring these agents will be removed from the study. Allowed: Sedative-hypnotic agents if dosage has been stable for 4 weeks prior to study entry; thyroid or estrogen replacement provided dosage has been stable for 3 months. Acceptable anticonvulsants include lamotrigine, valproate, gabapentin, topiramate, oxcarbazepine, carbamazepine.

Locations and Contacts

Roy H Perlis, MD, MSc, Email: rperlis@chgr.mgh.harvard.edu

Massachusetts General Hospital, Boston, Massachusetts 02114, United States; Recruiting
Roy H Perlis, MD MSc, Phone: 617-726-7426, Email: rperlis@chgr.mgh.harvard.edu
Ashlee Roberson, BA, Phone: 617-643-6310, Email: aroberson2@mgh.harvard.edu
Roy H Perlis, MD, MSc, Principal Investigator
Additional Information

Starting date: February 2013
Last updated: June 24, 2014

Page last updated: August 20, 2015

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