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Gut Hormones After Oral Versus Intravenous Amino Acids

Information source: Lund University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Normal Non-fluency

Intervention: Oral amino acid mixture (Other); Intravenous amino acid administration (Other)

Phase: N/A

Status: Completed

Sponsored by: Lund University

Official(s) and/or principal investigator(s):
Bo Ahrén, PhD, Principal Investigator, Affiliation: Lund University


The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.

Clinical Details

Official title: Release of Gut Hormones After Oral Versus Intravenous Amino Acids

Study design: Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome: Gut hormone secretion

Secondary outcome: Insulin secretion

Detailed description: Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects. Samples are taken regularly for 300 min after administrations. Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.


Minimum age: 20 Years. Maximum age: 30 Years. Gender(s): Male.


Inclusion Criteria:

- Healthy subjects

Exclusion Criteria:

- Diabetes

- Liver disease

- Kidney disease

- Thyroid disease

Locations and Contacts

Department of Clinical Sciences Lund, Lund University, Lund 221 84, Sweden
Additional Information

Starting date: May 2011
Last updated: October 9, 2012

Page last updated: August 23, 2015

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