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Outcome of Three Controlled Ovarian Hyperstimulation Protocols in Poor Responding Infertility Patients

Information source: Istanbul University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Infertility

Intervention: FSH 225IU and hMG 225IU (Drug); FSH 150IU and hMG 150IU (Drug); Letrozole 5mg and hMG 150IU (Drug)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Istanbul University

Summary

There are different controlled ovarian hyperstimulation protocols utilized in infertility patients. In this study, our aim is to specifically compare three protocols in poor responding infertility patients.

Clinical Details

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Clinical pregnancy rate

Secondary outcome:

Number of oocytes retrieved

Number of transferable embryos

Biochemical pregnancy rate

Eligibility

Minimum age: 18 Years. Maximum age: 42 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Patients will be considered eligible if they are poor ovarian responders according to

the Bologna criteria (Ferraretti et al., 2011).

- Two out of three of the following criteria are essential in order to classify a

patient as poor ovarian responder:

- advanced maternal age (≥40 years) or any other risk factor for poor ovarian

response;

- a poor ovarian response (≤3 oocytes with a conventional stimulation protocol);

or

- an abnormal ovarian reserve test (antral follicle count, <7 follicles or

anti-Mullerian hormone, <1. 1 ng/ml).

Locations and Contacts

Istanbul University School of Medicine, Istanbul 34093, Turkey
Additional Information

Related publications:

Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L; ESHRE working group on Poor Ovarian Response Definition. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011 Jul;26(7):1616-24. doi: 10.1093/humrep/der092. Epub 2011 Apr 19.

Starting date: November 2014
Last updated: May 9, 2015

Page last updated: August 23, 2015

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