Outcome of Three Controlled Ovarian Hyperstimulation Protocols in Poor Responding Infertility Patients
Information source: Istanbul University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Infertility
Intervention: FSH 225IU and hMG 225IU (Drug); FSH 150IU and hMG 150IU (Drug); Letrozole 5mg and hMG 150IU (Drug)
Phase: N/A
Status: Active, not recruiting
Sponsored by: Istanbul University
Summary
There are different controlled ovarian hyperstimulation protocols utilized in infertility
patients. In this study, our aim is to specifically compare three protocols in poor
responding infertility patients.
Clinical Details
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Clinical pregnancy rate
Secondary outcome: Number of oocytes retrievedNumber of transferable embryos Biochemical pregnancy rate
Eligibility
Minimum age: 18 Years.
Maximum age: 42 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- Patients will be considered eligible if they are poor ovarian responders according to
the Bologna criteria (Ferraretti et al., 2011).
- Two out of three of the following criteria are essential in order to classify a
patient as poor ovarian responder:
- advanced maternal age (≥40 years) or any other risk factor for poor ovarian
response;
- a poor ovarian response (≤3 oocytes with a conventional stimulation protocol);
or
- an abnormal ovarian reserve test (antral follicle count, <7 follicles or
anti-Mullerian hormone, <1. 1 ng/ml).
Locations and Contacts
Istanbul University School of Medicine, Istanbul 34093, Turkey
Additional Information
Related publications: Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L; ESHRE working group on Poor Ovarian Response Definition. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011 Jul;26(7):1616-24. doi: 10.1093/humrep/der092. Epub 2011 Apr 19.
Starting date: November 2014
Last updated: May 9, 2015
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