Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty
Information source: Mahidol University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Serum Bupivacaine Level; Periarticular Block; Total Knee Arthroplasty
Intervention: Bupivacaine (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Mahidol University
Summary
Patients with knee arthroplasty usually performed under spinal anesthesia with a single-shot
femoral nerve block and periarticular block, so we would like to know the plasma
concentration of bupivacaine in these patients.
Clinical Details
Official title: Plasma Concentrations of Bupivacaine After Spinal Anesthesia With Single Shot Femoral Nerve Block and Peri-articular Injection in Total Knee Arthroplasty
Study design: Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: plasma concentration of bupivacaine after spinal anesthesia with single-shot femoral nerve block and periarticular block
Secondary outcome: bupivacaine toxicity
Eligibility
Minimum age: 30 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- age of 30-70 yr
- ASA I-II
- patient undergo total knee arthroplasty under spinal block and single shot femoral
nerve block and periarticular block
Exclusion Criteria:
- patient's refusal
- allergic to bupivacaine
- body weight less than 50 kg
- liver disease
- heart disease
- coagulopathy
- Hct<35%
- infection at both groin
Locations and Contacts
Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Additional Information
Starting date: July 2012
Last updated: July 25, 2014
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