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Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty

Information source: Mahidol University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Serum Bupivacaine Level; Periarticular Block; Total Knee Arthroplasty

Intervention: Bupivacaine (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Mahidol University

Summary

Patients with knee arthroplasty usually performed under spinal anesthesia with a single-shot femoral nerve block and periarticular block, so we would like to know the plasma concentration of bupivacaine in these patients.

Clinical Details

Official title: Plasma Concentrations of Bupivacaine After Spinal Anesthesia With Single Shot Femoral Nerve Block and Peri-articular Injection in Total Knee Arthroplasty

Study design: Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome: plasma concentration of bupivacaine after spinal anesthesia with single-shot femoral nerve block and periarticular block

Secondary outcome: bupivacaine toxicity

Eligibility

Minimum age: 30 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- age of 30-70 yr

- ASA I-II

- patient undergo total knee arthroplasty under spinal block and single shot femoral

nerve block and periarticular block Exclusion Criteria:

- patient's refusal

- allergic to bupivacaine

- body weight less than 50 kg

- liver disease

- heart disease

- coagulopathy

- Hct<35%

- infection at both groin

Locations and Contacts

Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Additional Information

Starting date: July 2012
Last updated: July 25, 2014

Page last updated: August 23, 2015

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