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A Pilot Study of the Efficacy of Recombinant Alpha Interferon (IFN-A2b) and Zidovudine (AZT) in the Treatment of Progressive Multifocal Leukoencephalopathy (PML) Complicating HIV-1 Infection

Information source: NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: HIV Infections; Leukoencephalopathy, Progressive Multifocal

Intervention: Interferon alfa-2b (Drug); Zidovudine (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Miami

Summary

To study the effectiveness of alpha interferon (IFN-A2b) and zidovudine (AZT) in treating progressive multifocal leukoencephalopathy (PML) as a complication of HIV-1 infection.

Clinical Details

Official title: A Pilot Study of the Efficacy of Recombinant Alpha Interferon (IFN-A2b) and Zidovudine (AZT) in the Treatment of Progressive Multifocal Leukoencephalopathy (PML) Complicating HIV-1 Infection

Study design: Primary Purpose: Treatment

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria Patients must have:

- HIV seropositivity by both ELISA and Western blot.

- Biopsy proven progressive multifocal leukoencephalopathy (PML).

Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded:

- Intolerant to interferon.

- Prior or concomitant central nervous system disease (CNS) such as toxoplasmosis,

multiple sclerosis (MS), or neurosyphilis. Patients with the following are excluded:

- Intolerant to interferon.

- Prior or concomitant central nervous system disease (CNS) such as toxoplasmosis,

multiple sclerosis (MS), or neurosyphilis. Prior Medication: Excluded:

- Patients receiving interferon for other reasons.

Locations and Contacts

Univ of Miami School of Medicine, Miami, Florida 33136, United States
Additional Information


Last updated: June 23, 2005

Page last updated: August 23, 2015

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