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Striatal and Extra-striatal Mechanisms of Falling in Parkinson's Disease

Information source: University of Michigan
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Parkinson's Disease

Intervention: This is an observational study. Medical and radiological records will only be observed/reviewed. (Other)

Phase: N/A

Status: Completed

Sponsored by: University of Michigan


This research study will evaluate functions of memory, thinking, eye movements and walking and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using an imaging procedure called positron emission tomography (PET). You may know that the brain chemical dopamine, a "neurotransmitter" substance (a chemical messenger that nerve cells need to communicate with each other), is important for the brain to control movements and that the brain chemical acetylcholine may have functions related to mental concentration and attention. At the present time, the investigators have no clear information how these two chemicals in the brain of patients with Parkinson's disease are related to the risk of falling.

Clinical Details

Study design: Observational Model: Case Control, Time Perspective: Prospective


Minimum age: 50 Years. Maximum age: 85 Years. Gender(s): Both.


Inclusion Criteria:

- Subjects considered for inclusion will be female or male subjects either currently

enrolled or eligible for care at the VA aged 50-85 years, or community volunteers.

- The racial, gender and ethnic characteristics of the proposed subjects population

reflect the demographics of the patient population of the VA. However, extra efforts will be made to recruit women and minorities (see table 5).

- Children will be excluded from the study.

- No exclusion criteria shall be based on race, ethnicity, gender, or asymptomatic HIV

status. Exclusion Criteria:

- Inability to stand or walk independently (i. e., patients in Hoehn and Yahr stage IV

and V).

- Vertiginous disorder.

- Orthostatic hypotension or unstable cardiovascular disease at risk of syncope (drop

in systolic blood pressure of > 20 mm Hg upon standing).

- History of stroke with focal cortical lesions.

- Cerebellar, myelopathic or significant radiculopathy syndrome.

- Diminished light perception in both eyes (< 20/40 corrected OU).

- Intracranial surgery.

- Subjects who have participated in other research protocols such that their cumulative

radiation absorbed dose to whole body, gonads, bone marrow or lens of the eye would exceed 5 Rem, or dose to other body organs is more than 15 Rem in preceding 12 months.

- Pregnancy (beta-HCG test within 48 hours of PET study) or breastfeeding.

- Contra-indications to MRI.

Locations and Contacts

University of Michigan Functional Neuroimaging, Cognnitive and Mobility Laboratory, Ann Arbor, Michigan 48106, United States
Additional Information

Starting date: July 2006
Last updated: May 1, 2012

Page last updated: August 23, 2015

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