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Deciphering the Role of Oxytocin in Motivation: an fMRI Study

Information source: University of Michigan
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Focus of Study: Neural Correlates of Oxytocin Administration

Intervention: Placebo (Drug); Oxytocin (Drug)

Phase: Phase 2

Status: Active, not recruiting

Sponsored by: Tiffany Love

Official(s) and/or principal investigator(s):
Tiffany M Love, PhD, Principal Investigator, Affiliation: University of Michigan

Summary

The proposed study will investigate the effects of intranasal oxytocin administration on neural activity associated with social and non-social motivation.

Clinical Details

Official title: Deciphering the Role of Oxytocin in Motivation: an fMRI Study

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Primary outcome: Functional Magnetic Resonance Imaging (fMRI) Data: Change in BOLD Activity Between Placebo and Oxytocin Treatment.

Detailed description: Oxytocin is a well-known social and reproductive hormone demonstrated to have a variety of prosocial effects in humans including enhancing trust and generosity, improving positive communication, increasing eye gaze, and reducing anxiety. Oxytocin is hypothesized to facilitate social behaviors via its modulation of motivational networks. With this study, we will characterize oxytocin's effects on the neural processing of salient stimuli. We will utilize a noninvasive brain imaging technique, functional magnetic resonance imaging (fMRI), to assess brain activity while participants perform tests designed to engage neural circuits associated with the processing of social and non-social stimuli.

Eligibility

Minimum age: 20 Years. Maximum age: 35 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Male

- 20-35 years of age at the time of screening

- Right-handedness

- Non-smoking

- No current or past history of neurological or psychiatric illness, including

substance abuse or dependence

- No acute medical illness

- Written informed consent obtained from subject

Exclusion Criteria:

- Female

- Left-handedness or ambidextrous

- Presence of a condition or abnormality that in the opinion of the Investigator would

compromise the safety of the patient or the quality of the data

- Known allergies to oxytocin or to preservatives in the nasal spray

- Participants who exhibit nasal obstruction or upper-respiratory tract infection at

the time of scanning or report the use of intranasally administered medications for up to two weeks prior to screening

- Participants unable to tolerate the scanning procedures or would be unfit for

scanning purposes (e. g. metal implants, claustrophobic, unable to lie still for the duration of the scan)

- Any current or past history of medical, neurological, or psychiatric illness or

family history of psychiatric or neurologic disease in first-degree relatives

- Neurological illness, abnormal MRI (except if due to technical factors)

- Acute or uncorrected medical illnesses, including history of hepatic or renal

dysfunction.

- Participants currently taking medications including any treatment, current or past

with antipsychotics, mood stabilizers, isoniazid, glucocorticoids, psychostimulants and psychostimulant appetite suppressants, or centrally active antihypertensive drugs (e. g., clonidine, reserpine).

- Treatment within six months with any of the following: hormone use (testosterone,

DHEA), antidepressants, opioid drugs.

- Treatment within one month with sedative hypnotic medications (benzodiazepines,

barbiturates), or over the counter sleeping aids

- Current or past history of substance abuse or dependence

- Any reported lifetime use of any category of illicit drugs

- Positive urine drug screen

Locations and Contacts

University of Michigan, Ann Arbor, Michigan 48109, United States
Additional Information

Starting date: October 2012
Last updated: June 30, 2015

Page last updated: August 23, 2015

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