DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Influence of CPB and Mini CPB to the Absorption of the Metoprolol

Information source: Kuopio University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Drug Absorption

Intervention: blood concentration of metoprolol (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Kuopio University Hospital

Summary

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Clinical Details

Official title: Influence of CPB and Mini CPB to the Absorption of the Metoprolol After CABG

Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Primary outcome: absorbtion of the metoprolol

Secondary outcome: atrial fibrillation

Detailed description: Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion. Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol. Sudy is randomized into 3 groups: 1. Miniperfusion n. 15 2. Perfusion n. 15 3. offpump n. 15

Eligibility

Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria: elective CABG patient -

Exclusion Criteria: contraindication to metoprolol

-

Locations and Contacts

Kuopio University Hospital, Kuopio 70100, Finland; Recruiting
Martin Maaroos, MD, Phone: 358400218801, Email: martin.maaroos@kuh.fi
Martin Maaroos, MD, Principal Investigator
Additional Information

Starting date: November 2012
Last updated: August 19, 2015

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017