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Does Adding Bevacizumab Therapy in Glaucoma Surgery Improve the Success of Needle Bleb Revisions?

Information source: Wills Eye
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Glaucoma

Intervention: bevacizumab (Drug); balanced salt solution (Other)

Phase: Phase 2/Phase 3

Status: Completed

Sponsored by: Wills Eye

Official(s) and/or principal investigator(s):
Marlene R Moster, MD, Principal Investigator, Affiliation: Wills Eye


The purpose of this study is to see if a new add on (or adjunctive) therapy used in glaucoma surgery improves the success of needle bleb revisions.

Clinical Details

Official title: Does a New Add on (or Adjunctive) Therapy Used in Glaucoma Surgery Improve the Success of Needle Bleb Revisions?

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Intraocular Pressure (IOP)

Secondary outcome: Improvement in Filtering Blebs Morphology

Detailed description: To investigate the efficacy of needle bleb revisions with mitomycin C with subconjunctival bevacizumab in promoting both filtering success and favorable bleb morphologic features.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- require glaucoma bleb needle revision with Mitomycin-C

Exclusion Criteria:

- pregnant, nursing, or not using adequate contraception

- other glaucoma eye surgery involving tube shunts

- prior retinal detachments surgery with scleral buckle

- infection, inflammation, or any abnormality preventing eye pressure measurement

- enrolled in another investigational study

Locations and Contacts

Wills Eye Institute, Glaucoma Service, Philadelphia, Pennsylvania 19107, United States
Additional Information

Starting date: February 2009
Last updated: March 11, 2015

Page last updated: August 20, 2015

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