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The Hemodynamic Response to Prolonged Dobutamine Infusion

Information source: Hadassah Medical Organization
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy; Heart Failure

Intervention: 3 hours intravenous dobutamine (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Hadassah Medical Organization

Summary

A decrease in the response of beta 1 adrenergic receptors to agonists (desensitization) is thought to play a major role in the pathogenesis of diseases such as congestive heart failure. However, currently, there is no in vivo model that will enable us to measure desensitization of the hemodynamic responses to beta 1 adrenergic receptors in vivo. Our hypothesis is that constant 3 hours intravenous infusion of the selective beta1 adrenergic receptor agonist dobutamine will result in gradual decline in hemodynamic responses to dobutamine over time.

Clinical Details

Study design: Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label

Primary outcome: Heart rate

Secondary outcome: Systolic blood pressure

Eligibility

Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- healthy subjects

Exclusion Criteria:

- consumption of any medications during the 2 weeks prior to the study

- history of chest pain or tachycardia

Locations and Contacts

Hadassah University Hospital, Jerusalem 91120, Israel; Recruiting
Mordechai Muszkat, MD, Phone: 972-2-6777335, Email: muszkatm@hadassah.org.il
Mordechai Muszkat, MD, Principal Investigator
Additional Information

Related publications:

Bruck H, Leineweber K, Temme T, Weber M, Heusch G, Philipp T, Brodde OE. The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. J Am Coll Cardiol. 2005 Dec 6;46(11):2111-5. Epub 2005 Nov 4.

Starting date: January 2010
Last updated: July 3, 2011

Page last updated: August 20, 2015

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