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HCG Versus Spontaneous LH in Intrauterine Insemination (IUI ) Cycles

Information source: Universitair Ziekenhuis Brussel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Spontaneous Triggering of Ovulation vs. Administration of Human Chorionic Gonadotropin in Patients Undergoing IUI

Intervention: HCG (Drug)

Phase: Phase 0

Status: Completed

Sponsored by: Universitair Ziekenhuis Brussel

Summary

We recently reported the superiority of the natural cycle to a natural cycle controlled by the administration of human chorionic gonadotropin (hCG) for planning the frozen-thawed embryo transfer cycles, demonstrating a probable negative impact of exogenous hCG on endometrial receptivity. Based on the above findings we conducted the first prospective study that assesses whether there is a difference in pregnancy rate after intrauterine insemination (IUI) in a natural cycle with spontaneous luteinizing hormone (LH) rise compared to natural cycles controlled by hCG for final ovulation.

Clinical Details

Official title: Spontaneous Triggering of Ovulation vs. Administration of Human Chorionic Gonadotropin in Patients Undergoing Intrauterine Insemination: a Prospective Randomized Study.

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: ongoing pregnancy rate

Eligibility

Minimum age: 18 Years. Maximum age: 36 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- age ≤ 36 years,

- regular menstrual cycles,

- body mass index (BMI) between 18 and 29 kg/m²,

- basal levels of FSH (≤ 12 IU/l),

- estradiol (≤ 80 pg/ml) and progesterone (≤ 1. 6ng/ml) on day one of the cycle, normal

hysterosalpingography (maximum 3 months prior starting the cycle).

- The use of donor sperm was also accepted as inclusion criteria.

Exclusion Criteria:

- PCOS

- endometriosis

Locations and Contacts

Uzbrussel, Brussel, Laarbeeklaan 101 1090, Belgium
Additional Information

Starting date: April 2009
Last updated: August 10, 2011

Page last updated: August 23, 2015

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