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Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy

Information source: Medical University of Graz
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Pain

Intervention: Pregabalin (Drug); Placebo (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: Medical University of Graz

Official(s) and/or principal investigator(s):
Andreas Sandner-Kiesling, MD, Study Chair, Affiliation: Medical University of Graz
Helmar Bornemann-Cimenti, MD, DSc, Principal Investigator, Affiliation: Graz Medical University

Summary

Pregabalin 300mg or placebo are administered 1 hour preoperatively in patients undergoing elective nephrectomy. Postoperatively, patients receive a patient controlled analgesia device for self delivering opioids. Morphine consumption in the first 48 hours is documented. Hyperalgesia is measured by von-Frey-Filaments.

Clinical Details

Official title: Effect of Preoperative Pregabalin Administration on the Postoperative Opioid Consumption in Patients Undergoing Nephrectomy

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome: postoperative opioid consumption

Eligibility

Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patients undergoing elective nephrectomy

Exclusion Criteria:

- contraindication against pregabalin

- creatinine > 2. 0 mg/dl

- GGT >165, AST >105, ALT >135

- peptic Ulcus

- haemorrhagic diathesis

- angina pectoris, myocardial infarction

- stroke

- bronchial asthma

- opioid abuse

Locations and Contacts

Medical University of Graz, Graz 8036, Austria
Additional Information

Medical University of Graz

Starting date: April 2009
Last updated: May 26, 2011

Page last updated: August 23, 2015

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