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Tolerance to Target Doses of Thiazides in Actual Practice: A Feasibility Study

Information source: VA Pharmacy Benefits Management Strategic Healthcare Group
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension

Intervention: Favor one of two thiazides for new prescriptions & attempt target dose (Other)

Phase: Phase 4

Status: Completed

Sponsored by: VA Pharmacy Benefits Management Strategic Healthcare Group

Official(s) and/or principal investigator(s):
Madeline McCarren, PhD, MPH, Principal Investigator, Affiliation: VA Pharmacy Benefits Management

Summary

This is a pilot study of a method to compare common, FDA-approved drugs in a clinic. Instead of putting single patients into one of two drug groups, the investigators will assign the doctors who prescribe these drugs for high blood pressure into two groups. One group of doctors has agreed to prescribe mostly ("favor") one drug, chlorthalidone, if that drug would be a good choice for a patient. The other group has agreed to prescribe mostly hydrochlorothiazide. For both groups, they will try to use the doses that were shown to be protective in other trials. If the doctors mostly prescribe the drug they agreed to favor, the investigators will be able to compare outcomes, like heart attacks, in the two groups.

Clinical Details

Official title: Tolerance to Target Doses of Thiazides in Actual Practice: A Feasibility Study

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Primary outcome: Prescription Rates

Secondary outcome: Factors Associated With Prescribing Patterns

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- VA prescribers of thiazides for hypertension

Exclusion Criteria:

- at non-participating VA sites

Locations and Contacts

Edward Hines, Jr. VA Hospital, Hines, Illinois 60141, United States

Charles George VAMC, Asheville, North Carolina 28805, United States

Wilkes-Barre VA Medical Center, Wilkes-Barre, Pennsylvania 18711, United States

WJB Dorn VA Medical Center, Columbia, South Carolina 29209, United States

WJB Dorn VAMC/Columbia Orangeburg VA Outpatient Clinic, Orangeburg, South Carolina 29118, United States

Additional Information

Starting date: September 2011
Last updated: November 17, 2014

Page last updated: August 23, 2015

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