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Atacand (Candesartan) Real Life Study

Information source: AstraZeneca
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension

Intervention: Candesartan Cilexetil (Drug); Losartan (Drug)

Phase: N/A

Status: Completed

Sponsored by: AstraZeneca

Official(s) and/or principal investigator(s):
Jan Stålhammar, MD, Principal Investigator, Affiliation: Eriksbergs vårdcentral

Summary

This study is a Swedish historical cohort study in patients prescribed Atacand or Cozaar for hypertension by selected primary care centres. Data will be extracted anonymously from electronic medical records. In addition, data regarding morbidity and mortality will be collected by merging the cohort with the following national registries: the Hospital Discharge Register (Slutenvårdsregistret), the Cause of Death Register and the Heart Intensive Care Admission (RIKS-HIA)

Clinical Details

Official title: A REtrospective Study on the Effects of cAndesartan vs. Losartan on Blood Pressure, Health Care Consumption and cardiovascuLar Events In a "Real-liFe" GP sEtting in Sweden

Study design: Observational Model: Cohort, Time Perspective: Retrospective

Primary outcome: The primary efficacy objective is to investigate, on basis of 'first to event', the development of new cardiovascular diseases (CVD).

Secondary outcome:

Cardiovascular disease states and procedures in the background and over the entire observation period will be identified by use of ICD-9 and ICD-10 coding for diseases of the cardiovascular system. Specifically are death, acute cardiovascular events, new

Health care consumption will be assessed as contacts with health care providers, in-hospital time periods for cardiovascular disease states with associated therapeutic procedures, and times spent within various levels of care (e.g. ICU and general ward).

Eligibility

Minimum age: 17 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Recorded blood pressure prior to therapy of > 140 and/or 90 mmHg

- Diagnosed as hypertensive within 15 months

- First prescription of Cozaar or Atacand between 1 January 1999 and 31 December 2007,

inclusive Exclusion Criteria:

- Previous prescription within 15 months any drug from the ATC groups C02, C03, C07 -

C09 inclusive

Locations and Contacts

Research Site, Uppsala, Sweden
Additional Information

Starting date: March 2008
Last updated: December 1, 2010

Page last updated: August 20, 2015

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