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Effects of Methylprednisolone After Total Knee Arthroplasty

Information source: Hvidovre University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Pain; Postoperative Nausea and Vomiting; Sleeping Quality; Fatigue; Inflammatory Response

Intervention: Methylprednisolone (Drug); Placebo (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Hvidovre University Hospital


The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after knee arthroplasty. The hypothesis is that pre-operative methylprednisolone (125mg iv) will reduce pain and improve outcome.

Clinical Details

Official title: Effects of Pre-operative Methylprednisolone (125mg iv) After Total Knee Arthroplasty: A Prospective, Randomized, Double-blind, Placebo-controlled Trail

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care

Primary outcome: Postoperative pain

Secondary outcome:

Postoperative nausea and vomiting (PONV)

Sleeping quality

Inflammatory response

Additional analgetics, antinausea agents and sleeping medicine

Time in hospital


Detailed description: In spite of being one of the last century's most successful surgical procedures in treatment of advanced osteoarthritis total knee arthroplasty is still associated with postoperative pain and delayed rehabilitation. We therefore decided to evaluate the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome in a well defined fast-track setup after knee arthroplasty.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Elective total knee arthroplasty

- Able to speak and understand danish

- Able to give informed consent

Exclusion Criteria:

- Alcohol or medical abuse

- Allergies to local anesthetics or methylprednisolone

- Age < 18 years

- Daily use of opioids or glucocorticoids

- Pregnancy or breastfeeding (fertile women)

Locations and Contacts

Hvidovre University Hospital, Copenhagen, Hvidovre 2650, Denmark
Additional Information

Starting date: August 2009
Last updated: September 25, 2012

Page last updated: August 23, 2015

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