Fluoxetine vs. Brief Psychotherapy for Major Depression
Information source: University of Turku
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Major Depressive Disorder
Intervention: Fluoxetine (Drug); Short-term psychodynamic psychotherapy (Behavioral)
Phase: N/A
Status: Completed
Sponsored by: University of Turku Official(s) and/or principal investigator(s): Hasse Karlsson, MA, MD, PhD, Principal Investigator, Affiliation: Helsinki University
Summary
In this study we compare two treatments for major depression - fluoxetine and brief
psychodynamic psychotherapy. In addition to more traditional outcome measures, we also
measure the densities of 5HT-1A and D-2 receptors before and after the treatment. The main
hypothesis is that brief psychotherapy is as effective as fluoxetine.
Clinical Details
Official title: Fluoxetine vs. Brief Psychotherapy in the Treatment of Major Depression - a Randomized Comparative Study
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: HAM-D
Detailed description:
This study is a randomized comparison of two treatments for major depression - fluoxetine
and brief psychodynamic psychotherapy. The patients are recruited from occupational health
services and suffer from mild to moderate major depressive disorder. The treatments last for
16 weeks. The main outcome measures include HAM-D, BDI, SOFAS, Rand-36. In addition to more
traditional outcome measures, we also measure the densities of 5HT-1A and D-2 receptors
before and after the treatment using Positron Emission Tomography (PET) . The main
hypothesis is that brief psychotherapy is as effective as fluoxetine, but differences
between the treatments are seen in PET scanning.
Eligibility
Minimum age: 20 Years.
Maximum age: 60 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- MDD (mild to moderate)
- HDRS 15 or more, age 20-60 years
- No treatment for preceding 4 months
- No DSM-IV axis I or II comorbidity
- No severe somatic illness
- No contraindications for fluoxetine treatment
Locations and Contacts
Additional Information
Starting date: January 2000
Last updated: July 7, 2008
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