Studies of Psychiatric Predisposing Factors, Treatment-related Cardiovascular Effects, and Prognostic Factors Associated With Antimuscarinic Drug (Tolterodine) for Female Overactive Bladder Syndrome
Information source: National Taiwan University Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Antimuscarinic Drug
Intervention: tolterodine, solifenacin (Drug)
Phase: N/A
Status: Completed
Sponsored by: National Taiwan University Hospital
Summary
Overactive bladder syndrome (OAB) affects around 17 % of female population. However, the
etiology of OAB was complicated and unclear in many aspects. In particular, the research
about psychiatric aspect of etiology in OAB was paucity. Besides, research about prognostic
factors and impact of cardiovascular system of OAB treatment was also paucity. Therefore the
aims of the investigators study were (1) to analyze the etiology of OAB in psychiatric
aspects; (2) to analyze the prognostic factors associated with tolterodine treatment; (3) to
analyze the differences of cardiac conduction and heart rate variability before and after
tolterodine treatment; (4) to analyze the differences of arterial stiffness between non-OAB
and OAB female patients, and before and after tolterodine treatment.
Clinical Details
Official title: Studies of Psychiatric Predisposing Factors, Treatment-related Cardiovascular Effects, and Prognostic Factors Associated With Antimuscarinic Drug (Tolterodine) for Female Overactive Bladder Syndrome
Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Changes of heart rate variability after antimuscarinics
Secondary outcome: Changes of arterial stiffness after antimuscarinics treatmentChanges of psychologic distress after antimuscarinics treatment
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- all cases are female patients with lower urinary tract symptoms
Locations and Contacts
Department of Gynecology,National Taiwan University Hospital, Taipei, Taiwan
Additional Information
Starting date: August 2008
Last updated: October 30, 2013
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