Hematotoxic Effects of Particulate Exposure
Information source: National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cancer
Phase: N/A
Status: Completed
Sponsored by: National Institute of Environmental Health Sciences (NIEHS)
Summary
Hematotoxicity is caused by a number of agents such as a benzene by-product called
hydroquinone and the antitumor agent doxorubicin. This is a basic research study, conducted
using normal human donors, of mechanisms involved in hematotoxicity and of the protective
response of human hematopoietic progenitor cells to hematotoxic agents. Tumor necrosis
factor exposure protects these cells from a subsequent exposure to hematotoxic agents. The
alteration of gene expression in these cells caused by tumor necrosis factor is being
studied. Additionally, the tumor necrosis factor-induced biochemical pathways involved in
protection of human hematopoietic progenitor cells will be studied.
Clinical Details
Official title: Hematotoxic Effects of Benzene and Doxorubicin
Study design: Allocation: Random Sample
Eligibility
Minimum age: 18 Years.
Maximum age: 55 Years.
Gender(s): Both.
Criteria:
- healthy
- nonsmoking
- no history of hematologic disorder
- not pregnant
- no medications which suppress hematopoiesis
Locations and Contacts
Additional Information
Last updated: September 1, 2006
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