The ASPREE study will examine whether the potential benefits of low dose aspirin
(particularly preventing heart disease, stroke, certain cancers and dementia) outweigh the
risks (particularly bleeding) in people over age 65.
ASPREE will determine whether taking a daily low-dose aspirin will extend the length of a
disability-free life in healthy participants aged 65 years and above.
Minimum age: 65 Years.
Maximum age: N/A.
Gender(s): Both.
Inclusion Criteria:
- Men and women
- African American and Hispanic persons age 65 or older
- Any person from another ethnic minority group and Caucasian persons age 70 or older
- Willing and able to provide informed consent, and willing to accept the study
requirements
Exclusion Criteria:
- A history of a diagnosed cardiovascular event
- A serious intercurrent illness likely to cause death within the next 5 years, such as
terminal cancer or obstructive airways disease
- A current or recurrent condition with a high risk of major bleeding, ex: cerebral
aneurysm
- Anemia
- Absolute contraindication or allergy to aspirin
- Current participation in a clinical trial
- Current continuous use of aspirin or other anti-platelet drug or anticoagulant for
secondary prevention. People with previous use of aspirin for primary prevention may
enter the trial, provided they agree to cease existing use of aspirin and understand
that they may be subsequently randomly allocated to low dose aspirin or placebo.
- A systolic blood pressure ≥180 mmHg and / or a diastolic blood pressure ≥105 mmHg
- A history of dementia
- Severe difficulty or an inability to perform any one of the 6 Katz ADLs
- Non-compliance to taking pill
The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States
Palo Alto Medical Foundation Research Institute, Palo Alto, California 94301, United States
Howard University, Washington, District of Columbia 20060, United States
University of Florida Department of Aging and Geriatrics, Gainsville, Florida 32611, United States
Emory/ Atlanta VAMC, Atlanta, Georgia 30322, United States
Morehouse School of Medicine, Atlanta, Georgia 30310, United States
Georgia Health Sciences University, Augusta, Georgia 30912, United States
Rush Alzheimer's Disease Center, Chicago, Illinois 60612, United States
University of Iowa, Iowa City, Iowa 52242, United States
Kansas University Medical Center, Kansas City, Kansas 66106, United States
Baton Rouge General, Baton Rouge, Louisiana 70801, United States
Mary Bird Perkins Our Lady of the Lake Cancer Center, Baton Rouge, Louisiana 70809, United States
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, United States
Mary Bird Perkins St. Tammany Parish Hospital, Covington, Louisiana 70433, United States
Mary Bird Perkins Terrebonne General Hospital, Houma, Louisiana 70360, United States
LSU Health Sciences- New Orleans, New Orleans, Louisiana 70112, United States
Tulane Medical Center, New Orleans, Louisiana 70112, United States
LSU Health Sciences- Shreveport, Shreveport, Louisiana 71130, United States
University of Michigan, Ann Arbor, Michigan 48109, United States
Henry Ford Health System, Detroit, Michigan 48202, United States
Wayne State University, Detroit, Michigan 48201, United States
Detroit Clinical Research Center, Novi, Michigan 48377, United States
Health Partners Research Foundation, Minneapolis, Minnesota 55425, United States
Phalen Village Clinic, St. Paul, Minnesota 55106, United States
Central Jersey Medical Center, Elizabeth, New Jersey 07202, United States
New Jersey Medical College, Newark, New Jersey 07103, United States
SUNY Downstate Medical Center, Brooklyn, New York 11203, United States
Winthrop University Hospital, Mineola, New York 11501, United States
Queens Cancer Medical Center, Queens, New York 11432, United States
Wake Forest University Baptist Medical Center, Greensboro, North Carolina 27408, United States
The Brody School of Medicine at ECU, Greenville, North Carolina 27834, United States
Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141, United States
University of Pittsburgh Health Sciences Research Center, Pittsburgh, Pennsylvania 15260, United States
Memorial Hospital of Rhode Island, Pawtucket, Rhode Island 02860, United States
University of Tennessee Health Science Center, Memphis, Tennessee 38105, United States
Meharry Medical College, Nashville, Tennessee 57208, United States
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States
University of TX Medical Branch, Galveston, Texas 77555, United States
Regional Academic Health Center, Harlingen, Texas 78550, United States
UT Health Science Center at San Antonio, San Antonio, Texas 78229, United States