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Avastin as an Adjunct to Diode Laser in the Treatment of Neovascular Glaucoma

Information source: Cairo University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Neovascular Glaucoma

Intervention: Diode laser cyclophotocoagulation enhanced by intravitreal injection of Avastin (Procedure)

Phase: Phase 2

Status: Completed

Sponsored by: Cairo University

Official(s) and/or principal investigator(s):
Mostafa A EL-Helw, M.D., Principal Investigator, Affiliation: Cairo University


Assess the efficacy of Avastin as an adjunct to Diode Laser cyclophotocoagulation in the treatment of Neovascular Glaucoma.

Clinical Details

Official title: Avastin as an Adjunct to Diode Laser Cyclophotoablation in the Treatment of Neovascular Glaucoma

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Disappearance of iris neovessels

Secondary outcome: Intra ocular pressure

Detailed description: Design: Prospective, comparative interventional case series. Method: Patients were randomly assigned into Group A which were treated with Diode laser cyclophotocoagulation alone, whereas group B received intravitreal Avastin (One milligram = 0. 04mL of 25 mg/mL) in conjunction with the Diode Laser. The preoperative data included etiology, mean age; follow up period, and a full ophthalmological examination with emphasis on mean IOP, iris neovascularization, pain and corneal edema.


Minimum age: 14 Years. Maximum age: 72 Years. Gender(s): Both.


Inclusion Criteria:

- Neovascular absolute glaucoma

- Painful blind eyes

Exclusion Criteria:

- Neovascular glaucoma with useful vision or potential for useful vision

Locations and Contacts

Kasr El-Ainy hospital, Cairo university,ophthalmology departement, Cairo 11451, Egypt
Additional Information

Starting date: January 2006
Last updated: January 15, 2010

Page last updated: August 20, 2015

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