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Randomized Controlled Double Blind Trial of Short vs Long Acting Dihydrocodeine in Chronic Non-malignant Pain

Information source: Norwegian University of Science and Technology
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pain

Intervention: Dihydrocodeine (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Norwegian University of Science and Technology

Official(s) and/or principal investigator(s):
Petter C Borchgrevink, PhD, MD, Principal Investigator, Affiliation: Norwegian University of Science and Technology

Summary

We wish to compare the effect of long acting vs short acting opioids in chronic non-malignant pain. The study opioid is Dihydrocodeine Continus and Dihydrocodeine 30 mg tablets. We measure pain relief, health related quality of life, sleep, breakthrough pain and depression with validated questionnaires to compare the two treatment arms. Hypothesis: The pain relief will be better and more stable with long acting opioids. Quality of sleep, breakthrough pain and quality of life will also be improved with long acting dihydrocodeine.

Clinical Details

Official title: Randomized Controlled Double Blind Trial of Short vs Long Acting Dihydrocodeine in Chronic Non-Malignant Pain

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome: Pain

Secondary outcome:

sleep quality and duration

quality of life

Depression and moods

Eligibility

Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Chronic pain

- Use 5-10 P. Forte every day for the last two weeks

- 18-75 years.

Exclusion Criteria:

- Cancer

- Hepatic failure

- Severe mental disorders

- History of known substance abuse.

Locations and Contacts

National Competency Centre for Complex Disorders, Trondheim, Sør-Trøndelag 7049, Norway
Additional Information

Starting date: October 2007
Last updated: December 30, 2014

Page last updated: August 20, 2015

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