Randomized Controlled Double Blind Trial of Short vs Long Acting Dihydrocodeine in Chronic Non-malignant Pain
Information source: Norwegian University of Science and Technology
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pain
Intervention: Dihydrocodeine (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Norwegian University of Science and Technology Official(s) and/or principal investigator(s): Petter C Borchgrevink, PhD, MD, Principal Investigator, Affiliation: Norwegian University of Science and Technology
Summary
We wish to compare the effect of long acting vs short acting opioids in chronic
non-malignant pain. The study opioid is Dihydrocodeine Continus and Dihydrocodeine 30 mg
tablets. We measure pain relief, health related quality of life, sleep, breakthrough pain
and depression with validated questionnaires to compare the two treatment arms.
Hypothesis: The pain relief will be better and more stable with long acting opioids. Quality
of sleep, breakthrough pain and quality of life will also be improved with long acting
dihydrocodeine.
Clinical Details
Official title: Randomized Controlled Double Blind Trial of Short vs Long Acting Dihydrocodeine in Chronic Non-Malignant Pain
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Primary outcome: Pain
Secondary outcome: sleep quality and durationquality of life Depression and moods
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Chronic pain
- Use 5-10 P. Forte every day for the last two weeks
- 18-75 years.
Exclusion Criteria:
- Cancer
- Hepatic failure
- Severe mental disorders
- History of known substance abuse.
Locations and Contacts
National Competency Centre for Complex Disorders, Trondheim, Sør-Trøndelag 7049, Norway
Additional Information
Starting date: October 2007
Last updated: December 30, 2014
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