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Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer

Information source: Mashhad University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Malignant Neoplasm of Thyroid Stage I; Malignant Neoplasm of Thyroid Stage II

Intervention: Metformin (Drug)

Phase: N/A

Status: Completed

Sponsored by: Mashhad University of Medical Sciences

Summary

Differentiated thyroid cancer is the most common neoplasm of endocrine system. After surgery and radioiodine treatment, thyroid stimulating hormone (TSH) suppression is the main goal which is achieved with levothyroxine treatment. Levothyroxine causes increased thyroid hormones which can have negative impact on bone and cardiovascular system. Anecdotal reports have shown that metformin can induce TSH suppression without change in T3 and T4 concentration. The purpose of this study was to prescribe metformin as additional drug to levothyroxin in order to decrease levothyroxine dosage.

Clinical Details

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: TSH

Secondary outcome: freeT3,freeT4

Eligibility

Minimum age: N/A. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- papillary or follicular thyroid cancer

- stage 1 or 2 according to TNM system version 6

- surgery and radioiodine treatment

- levothyroxine suppression treatment

Exclusion Criteria:

- cardiopulmonary failure

- liver failure

- renal failure

- pregnancy

- drugs (colestyramin, sucralfate, phenobarbital, phenytoin, carbamazepin, rifampin,

amiodarone, chloroquin, androgens, sertraline, frusemide, heparin)

Locations and Contacts

Mashad University of Medical Sciences, Mashad, Khorasan Razavi, Iran, Islamic Republic of
Additional Information

Starting date: April 2010
Last updated: April 25, 2011

Page last updated: August 23, 2015

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