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The Relationships Between the Noradrenergic, Opioid and Pain System

Information source: Rambam Health Care Campus
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Experimental Pain Perception

Intervention: Clonidine (Drug); Naloxone (Drug); placebo (Drug); saline (Other)

Phase: N/A

Status: Not yet recruiting

Sponsored by: Rambam Health Care Campus

Overall contact:
David Yarnitsky, Prof., Email: d_yarnitsky@rambam.health.gov.il


The role of alpha2 receptor agonist on pain perception and modulation will be examined. In addition whether this is mediated through the opioid system will be examined. Pain perception and modulation will be examined before and after administration of Clonidine or placebo together with Naloxone or saline.

Clinical Details

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Primary outcome: The changes in pain responses after administration of alpha 2 agonist and mu receptor antagonist


Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Both.


Inclusion Criteria:

- Healthy volunteers

- Age 18-40

- No chronic disease

Exclusion Criteria:

- Subjects who suffer from chronic pain / pain syndrome

- use of anti-depressant or anti-psychotic drugs

- suffering from cardiovascular disease

- breast feeding

Locations and Contacts

David Yarnitsky, Prof., Email: d_yarnitsky@rambam.health.gov.il

Rambam Health Care Campus, Haifa, Israel; Not yet recruiting
David Yarnitsky, Email: d_yarnitsky@rambam.health.gov.il
Additional Information

Starting date: May 2013
Last updated: May 9, 2013

Page last updated: August 23, 2015

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