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Testing Mestinon and Exercise in Fibromyalgia

Information source: Oregon Health and Science University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Fibromyalgia

Intervention: Exercise (Behavioral); pyridostigmine (Drug); Placibo (Drug); Attention Control (Behavioral)

Phase: Phase 2

Status: Completed

Sponsored by: Oregon Health and Science University

Official(s) and/or principal investigator(s):
Edit Serfozo, MPH, Study Director, Affiliation: Oregon Health and Science University
Kim Dupree Jones, PhD, Principal Investigator, Affiliation: Oregon Health and Science University


The purpose of this trial was to test the combined and independent effects of 6 months of exercise and Mestinon in people with fibromyalgia. Specifically, we wanted to determine if Mestinon helped people with fibromyalgia have an easier time exercising and if their symptoms improved by the end of the trial.

Clinical Details

Official title: Maximizing Exercise Effectiveness in Fibromyalgia

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Levels of Growth Hormone Post Exercise

Secondary outcome: Improvement of Fibromyalgia Symptoms

Detailed description: Earlier, we demonstrated that people with fibromyalgia fail to make adequate growth hormone when they exercise intensively. We also demonstrated that a single dose of Mestinon helped people make normal levels of growth hormone when they exercised in our laboratory. We wanted to know if 6 months of exercise with concurrent Mestinon therapy would make growth hormone (and related markers) normal and improve fibromyalgia symptoms.


Minimum age: 21 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Have Fibromyalgia

Exclusion Criteria:

- Subjects will be excluded if they have a history of rheumatic disease or other

disorder that may compromise ability to safely complete study protocol, be pregnant, nursing, or currently involved in unresolved litigation.

Locations and Contacts

Oregon Health & Science University, Portland, Oregon 97219, United States
Additional Information

Starting date: September 2002
Last updated: March 23, 2011

Page last updated: August 23, 2015

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