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The Safety and Effectiveness of Retrovir in HIV-Infected Patients Who Have Problems Related to the Nervous System

Information source: NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: HIV Infections

Intervention: Zidovudine (Drug)

Phase: N/A

Status: Completed

Sponsored by: Glaxo Wellcome

Summary

To assess the efficacy of Retrovir (AZT) therapy in the treatment of HIV Ab positive persons with impairments in neuropsychological functioning. To assess the safety, virologic, and immunologic effects of AZT therapy in HIV Ab positive persons with neuropsychological impairment but minimal other symptomatology.

Clinical Details

Official title: Safety and Efficacy of Retrovir in HIV Infected Patients Having Neuropsychological Impairments

Study design: Primary Purpose: Treatment

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Exclusion Criteria Co-existing Condition: Patients with the following are excluded:

- Neuropsychological (NP) impairments more severe than described in the Inclusion

Criteria.

- Evidence of nervous system dysfunction being caused by factors other than HIV

infection, including history of head trauma, multiple sclerosis, epilepsy, or presence of concurrent central nervous system (CNS) infections or neoplasms, e. g., toxoplasmosis, primary or metastatic CNS lymphoma, progressive multifocal leukoencephalopathy, cryptococcal or other fungal meningitis, and CNS tuberculous infections.

- Lymphoma or other tumor requiring cytotoxic chemotherapy.

Concurrent Medication: Excluded:

- Other antiretroviral agents.

Patients with the following are excluded:

- AIDS or advanced ARC.

- Neuropsychological (NP) impairments more severe than described above; i. e., defective

performance on NP test battery in 3 or more NP areas on the NP screening battery at 2 standard deviations below the mean.

- Evidence of nervous system dysfunction being caused by factors other than HIV

infection, including history of head trauma, multiple sclerosis, epilepsy, or presence of concurrent central nervous system (CNS) metastatic CNS lymphoma, progressive multifocal leukoencephalopathy, cryptococcal or other fungal meningitis, and CNS tuberculous infections. Prior Medication: Excluded:

- Antiretroviral agents including zidovudine (AZT).

Prior Treatment: Excluded within 3 months of study entry:

- Blood transfusion.

Impaired performance on a defined neuropsychological test battery.

- Asymptomatic HIV infection.

- Persistent generalized lymphadenopathy (PGL).

- Early AIDS related complex (ARC).

- Seropositive for human immunodeficiency virus (HIV) demonstrated by positive ELISA

test and confirmed by Western blot with no or minimal symptomatology or HIV infection.

- Ability to give informed consent or a person with durable power of attorney who can

give informed consent.

- Willingness to be followed by the originating medical center for 1 year.

History of drug or alcohol abuse.

Locations and Contacts

Glaxo Wellcome Inc, Research Triangle Park, North Carolina 27709, United States
Additional Information


Last updated: June 23, 2005

Page last updated: August 23, 2015

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