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Intrathecal Morphine,Femoral Nerve Block,Periarticular Bupivacaine Infiltration for Pain After Intramedullary Hip Screw

Information source: Mahidol University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Femoral Neck Fractures

Intervention: Bupivacaine, morphine (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Mahidol University

Official(s) and/or principal investigator(s):
Thitima Chinachoti, M.D., Principal Investigator, Affiliation: Mahidol University

Overall contact:
Thitima Chinachoti, M.D., Phone: 66813082438, Email: sitci35@gmail.com


Falls are a common problem in elderly patients resulting fractured femur, which require early operation. Adequate postoperative pain control will provide good recovery. The investigators will compare the efficacy of postoperative pain control among intrathecal morphine, femoral nerve block, and periarticular infiltration with bupivacaine in patients undergone intramedullary hip screw under spinal anesthesia.

Clinical Details

Official title: Post Operative Pain Control Among Intrathecal 0.1 mg Morphine, Femoral Nerve Block, or Periarticular Infiltration of 20 mL of 0.25% Bupivacaine in Patients Post Intramedullary Hip Screw

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: The amount of morphine consumption.

Secondary outcome: Efficacy of pain control

Detailed description: Study methods : Every patients without any exclusion criteria will be performed spinal anesthesia by 0. 5% heavy bupivacaine then divided into 4 groups 1. Controlled group : spinal anesthesia alone 2. Femoral nerve block by 20 mL of 0. 25% bupivacaine before spinal anesthesia 3. Spinal anesthesia plus 0. 1 mg morphine intrathecally 4. Spinal anesthesia plus periarticular infiltration with 20 mL of 0. 25% bupivacaine All patients will receive postoperative intravenous patient controlled analgesia (IV PCA) morphine for 48 hours. Data collection 1. Demographic data 2. Pain score : preoperative, 3 hours postoperative in the 1st six hours, 12 hours postoperative by visual analog scoring system (VASS) 3. Patient global assessment and patient satisfactory VASS at 24 and 48 hours postoperative 4. The amount of morphine at 24 and 48 hours postoperative and the time of the 1st dose


Minimum age: 18 Years. Maximum age: 90 Years. Gender(s): Both.


Inclusion Criteria:

- 18-90 years old

- good consciousness, well co-operated, can use PCA machine

- ASA class 1-3

- no contraindication of spinal anesthesia

- accept for spinal anesthesia

- body weight > 30 kg

- BMI 20-35 kg/m2

- no history of research-drug allergy

Exclusion Criteria:

- previous history of hip surgery (the same side)

- pathological fractured such as severe infection, bone cancer

Locations and Contacts

Thitima Chinachoti, M.D., Phone: 66813082438, Email: sitci35@gmail.com

Faculty of Medicine Siriraj Hospital, Bangkok 10700, Thailand; Recruiting
Thitima Chinachoti, MD, Phone: 6681-3082438, Email: sitci35@gmail.com
Thitima Chinachoti, MD, Principal Investigator
Additional Information

Starting date: September 2010
Last updated: August 3, 2011

Page last updated: August 23, 2015

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