Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism
Information source: University of Lausanne
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Metabolic Syndrome
Intervention: control (Dietary Supplement); Fructose+maltodextrin placebo (Dietary Supplement); amino-acid + fructose (Dietary Supplement)
Phase: N/A
Status: Completed
Sponsored by: University of Lausanne
Summary
10 healthy male volunteers will be studied after
- a 6 day weight maintenance, balanced diet
- a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body
weight/day
- a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body
weight/day and 20g amino-acids per day At the end of each 6 days period, the following
measurements will be obtained
- intrahepatic lipids (1H-MRS)
- metabolic effects of fructose ingestion (measurement of substrate oxidation,
gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics)
This is a randomized, double blinded study
Clinical Details
Official title: Effects of a Supplementation With Amino-acids on Hepatic Lipid Metabolism
Study design: Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Basic Science
Primary outcome: intrahepatic lipids
Secondary outcome: 13C palmitate synthesis
Eligibility
Minimum age: 18 Years.
Maximum age: 30 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- age 18-30 years
- sex: males
- BMI between 19 and 25 kg/m2
- less than 3 30min- exercise session/week
Exclusion Criteria:
- smokers
- alcohol consumption more than 50g/week
- consumption of drugs
- history of diabetes in first degree relatives
- presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication
to NMR
Locations and Contacts
Centre Hospitalier Universitaire Vaudois, Lausanne, VD CH-1011, Switzerland
Additional Information
Starting date: May 2010
Last updated: February 23, 2012
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