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Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism

Information source: University of Lausanne
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Metabolic Syndrome

Intervention: control (Dietary Supplement); Fructose+maltodextrin placebo (Dietary Supplement); amino-acid + fructose (Dietary Supplement)

Phase: N/A

Status: Completed

Sponsored by: University of Lausanne

Summary

10 healthy male volunteers will be studied after

- a 6 day weight maintenance, balanced diet

- a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body

weight/day

- a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body

weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained

- intrahepatic lipids (1H-MRS)

- metabolic effects of fructose ingestion (measurement of substrate oxidation,

gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics) This is a randomized, double blinded study

Clinical Details

Official title: Effects of a Supplementation With Amino-acids on Hepatic Lipid Metabolism

Study design: Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Basic Science

Primary outcome: intrahepatic lipids

Secondary outcome: 13C palmitate synthesis

Eligibility

Minimum age: 18 Years. Maximum age: 30 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- age 18-30 years

- sex: males

- BMI between 19 and 25 kg/m2

- less than 3 30min- exercise session/week

Exclusion Criteria:

- smokers

- alcohol consumption more than 50g/week

- consumption of drugs

- history of diabetes in first degree relatives

- presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication

to NMR

Locations and Contacts

Centre Hospitalier Universitaire Vaudois, Lausanne, VD CH-1011, Switzerland
Additional Information

Starting date: May 2010
Last updated: February 23, 2012

Page last updated: August 23, 2015

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