Clinical and experimental studies suggest that bosentan could delay the progression of
interstitial lung disease (ILD) associated with systemic sclerosis (SSc), a condition for
which no established efficacious treatment is available. The present trial investigates a
possible use of oral bosentan, which is currently approved for the treatment of symptoms of
pulmonary arterial hypertension (PAH) WHO Class III and IV, to a new category of patients
suffering from ILD associated with SSc.
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Centre Hospitalier Universitaire, Grenoble, France
CHRU Claude Huriez, Lille, France
Hôpital Cochin, Paris, France
Hôpital Saint Antoine, Paris, France
Charité Universitätsklinikum, Berlin, Germany
Rabin Medical Center, Petach Tikva, Israel
Instituto di Clinica, Villa Monna Tessa, Firenze, Italy
Ospedale Maggiore, Milano, Italy
Policlinico Universitario, Padova, Italy
Sint Maartenskliniek, Nijmegen, Netherlands
University Hospital, Lund, Sweden
University Hospital, Zurich, Switzerland
General Infirmary, Leeds, United Kingdom
Royal Free Hospital, London, United Kingdom
UCLA Med School, Los Angeles, California 90095, United States
Denver Health Medical Center, Denver, Colorado 80204, United States
Georgetown University, Washington, District of Columbia 20007, United States
Jackson Memorial Hospital, Miami, Florida 33136, United States
University of Illinois College of Medicine, Chicago, Illinois 60612, United States
Boston Univ School of Medicine, Boston, Massachusetts 02118, United States
UMDNJ, New Brunswick, New Jersey 08903, United States
The Center for Rheumatology, Albany, New York 12206, United States
The Cleveland Clinic, Cleveland, Ohio 44195, United States
Thomas Jefferson University, Philadelphia, Pennsylvania 19004, United States
University of Pittsburgh, Pittsburgh, Pennsylvania 15267, United States
Medical Univ of South Carolina, Charleston, South Carolina 29425, United States
University of Texas Houston Medical School, Houston, Texas 77030, United States
University of Washington, Seattle, Washington 98195, United States
Virginia Mason Medical Center, Seattle, Washington 98101, United States