Effects of Vitamin A Supplementation on Intestinal Parasitic Reinfections
Information source: Sana'a University
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Intestinal Parasitic Infections; Malnutrition; Anemia
Intervention: vitamin A supplements (Drug); Placebo (Drug)
Phase: N/A
Status: Completed
Sponsored by: Sana'a University Official(s) and/or principal investigator(s): Hesham M Al-Mekhlafi, PhD, Principal Investigator, Affiliation: University of Malaya
Summary
Intestinal parasitic infections, malnutrition and iron deficiency anaemia (IDA) are still
considered as public health problems in rural Malaysia especially among Orang Asli children.
Despite intermittent control programmes, the prevalence of these problems is still high
suggesting the need of other control and interventions measures. This randomized
double-blind, placebo-controlled trial was carried out among Orang Asli schoolchildren from
Sekolah Kebangsaan Betau in Pos Betau, Pahang (200 km northeast Kuala Lumpur) to investigate
the effects of vitamin A supplementation on intestinal parasitic reinfections, growth, iron
status and educational achievement.
HYPOTHESES
1. Vitamin A supplementation has a negative effect on intestinal parasitic reinfections
and the worm burden of infections among Orang Asli schoolchildren in Pos Betau, Kuala
Lipis, Pahang.
2. Vitamin A supplementation has a positive effect on growth (weight and height) among
Orang Asli schoolchildren.
3. Vitamin A supplementation is effective in improving serum iron status among Orang Asli
schoolchildren.
4. Vitamin A supplementation has a positive effect on cognitive function and educational
achievement among Orang Asli schoolchildren.
Clinical Details
Official title: Effects of Vitamin A Supplementation on Intestinal Parasitic Reinfections, Growth, Iron Status and Educational Achievement Among Orang Asli Schoolchildren in Pos Betau, Pahang, Malaysia
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Primary outcome: intestinal parasitic infections
Secondary outcome: growth , iron status & educational achievement
Detailed description:
Children from Sekolah Kebangsaan Betau in Pos Betau, Kuala Lipis, Pahang served as the
target population for this study.
The selection criteria for study subjects were the following:
- Age 7-12 years (according to birth date in birth certificate).
- Non-menstruating females (age <13)
- No history or evidence of underlying haematological-related diseases such as
thalassaemia and ovalocytosis.
- No evidence of concomitant severe and/or chronic illness such as acute respiratory
tract infections, mental retardation and neurological deficits.
- Consent of parent to participate in the study.
Eligibility
Minimum age: 7 Years.
Maximum age: 12 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age 7-12 years (according to birth date in birth certificate).
- No evidence of concomitant severe and/or chronic illness such as acute respiratory
tract infections, mental retardation and neurological deficits.
- Consent of parent to participate in the study.
Exclusion Criteria:
- history or evidence of underlying haematological-related diseases such as
thalassaemia and ovalocytosis.
- menstruating females (age >13)
Locations and Contacts
National school of Pos Betau, Kuala Lipis, Pahang, Malaysia
Additional Information
Related publications: Donnen P, Brasseur D, Dramaix M, Vertongen F, Zihindula M, Muhamiriza M, Hennart P. Vitamin A supplementation but not deworming improves growth of malnourished preschool children in eastern Zaire. J Nutr. 1998 Aug;128(8):1320-7. Hadi H, Stoltzfus RJ, Dibley MJ, Moulton LH, West KP Jr, Kjolhede CL, Sadjimin T. Vitamin A supplementation selectively improves the linear growth of indonesian preschool children: results from a randomized controlled trial. Am J Clin Nutr. 2000 Feb;71(2):507-13. Payne LG, Koski KG, Ortega-Barria E, Scott ME. Benefit of vitamin A supplementation on ascaris reinfection is less evident in stunted children. J Nutr. 2007 Jun;137(6):1455-9. Tanumihardjo SA, Permaesih D, Muhilal. Vitamin A status and hemoglobin concentrations are improved in Indonesian children with vitamin A and deworming interventions. Eur J Clin Nutr. 2004 Sep;58(9):1223-30.
Starting date: May 2007
Last updated: August 3, 2009
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