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Effects of Vitamin A Supplementation on Intestinal Parasitic Reinfections

Information source: Sana'a University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Intestinal Parasitic Infections; Malnutrition; Anemia

Intervention: vitamin A supplements (Drug); Placebo (Drug)

Phase: N/A

Status: Completed

Sponsored by: Sana'a University

Official(s) and/or principal investigator(s):
Hesham M Al-Mekhlafi, PhD, Principal Investigator, Affiliation: University of Malaya

Summary

Intestinal parasitic infections, malnutrition and iron deficiency anaemia (IDA) are still considered as public health problems in rural Malaysia especially among Orang Asli children. Despite intermittent control programmes, the prevalence of these problems is still high suggesting the need of other control and interventions measures. This randomized double-blind, placebo-controlled trial was carried out among Orang Asli schoolchildren from Sekolah Kebangsaan Betau in Pos Betau, Pahang (200 km northeast Kuala Lumpur) to investigate the effects of vitamin A supplementation on intestinal parasitic reinfections, growth, iron status and educational achievement. HYPOTHESES 1. Vitamin A supplementation has a negative effect on intestinal parasitic reinfections and the worm burden of infections among Orang Asli schoolchildren in Pos Betau, Kuala Lipis, Pahang. 2. Vitamin A supplementation has a positive effect on growth (weight and height) among Orang Asli schoolchildren. 3. Vitamin A supplementation is effective in improving serum iron status among Orang Asli schoolchildren. 4. Vitamin A supplementation has a positive effect on cognitive function and educational achievement among Orang Asli schoolchildren.

Clinical Details

Official title: Effects of Vitamin A Supplementation on Intestinal Parasitic Reinfections, Growth, Iron Status and Educational Achievement Among Orang Asli Schoolchildren in Pos Betau, Pahang, Malaysia

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Primary outcome: intestinal parasitic infections

Secondary outcome: growth , iron status & educational achievement

Detailed description: Children from Sekolah Kebangsaan Betau in Pos Betau, Kuala Lipis, Pahang served as the target population for this study. The selection criteria for study subjects were the following:

- Age 7-12 years (according to birth date in birth certificate).

- Non-menstruating females (age <13)

- No history or evidence of underlying haematological-related diseases such as

thalassaemia and ovalocytosis.

- No evidence of concomitant severe and/or chronic illness such as acute respiratory

tract infections, mental retardation and neurological deficits.

- Consent of parent to participate in the study.

Eligibility

Minimum age: 7 Years. Maximum age: 12 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age 7-12 years (according to birth date in birth certificate).

- No evidence of concomitant severe and/or chronic illness such as acute respiratory

tract infections, mental retardation and neurological deficits.

- Consent of parent to participate in the study.

Exclusion Criteria:

- history or evidence of underlying haematological-related diseases such as

thalassaemia and ovalocytosis.

- menstruating females (age >13)

Locations and Contacts

National school of Pos Betau, Kuala Lipis, Pahang, Malaysia
Additional Information

Related publications:

Donnen P, Brasseur D, Dramaix M, Vertongen F, Zihindula M, Muhamiriza M, Hennart P. Vitamin A supplementation but not deworming improves growth of malnourished preschool children in eastern Zaire. J Nutr. 1998 Aug;128(8):1320-7.

Hadi H, Stoltzfus RJ, Dibley MJ, Moulton LH, West KP Jr, Kjolhede CL, Sadjimin T. Vitamin A supplementation selectively improves the linear growth of indonesian preschool children: results from a randomized controlled trial. Am J Clin Nutr. 2000 Feb;71(2):507-13.

Payne LG, Koski KG, Ortega-Barria E, Scott ME. Benefit of vitamin A supplementation on ascaris reinfection is less evident in stunted children. J Nutr. 2007 Jun;137(6):1455-9.

Tanumihardjo SA, Permaesih D, Muhilal. Vitamin A status and hemoglobin concentrations are improved in Indonesian children with vitamin A and deworming interventions. Eur J Clin Nutr. 2004 Sep;58(9):1223-30.

Starting date: May 2007
Last updated: August 3, 2009

Page last updated: August 20, 2015

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