Effects of Six Months of Moderate Resistance- Versus Endurance-Training on Muscle ATP Synthesis in First-Degree Relatives of Patients With Type 2 Diabetes
Information source: Landsteiner Institut
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Type 2 Diabetes Mellitus; Insulin Resistance
Intervention: exercise training, endurance training (Behavioral)
Phase: N/A
Status: Completed
Sponsored by: Landsteiner Institut Official(s) and/or principal investigator(s): Michael Roden, Prof., Study Director, Affiliation: Institute for Clinical Diabetology, German Diabetes Center (Leibniz Center for Diabetes Research), Department of Metabolic Diseases, Heinrich-Heine University and University Clinics Düsseldorf, Germany
Summary
Life style intervention including diet and exercise is the recommended strategy for
prevention of type 2 diabetes mellitus (T2DM). First-degree relatives of patients with type
2 diabetes mellitus have an increased risk of insulin resistance and a lifetime risk of
developing type 2 diabetes of 40%- 80%. Poor physical fitness is a strong indicator of an
increased risk of developing diabetes.
Long-term endurance exercise training has been shown to increase insulin sensitivity in
sedentary young and elderly individuals, first degree relatives of patients with Type 2
diabetes, glucose intolerant obese, or Type 2 diabetic humans. In type 2 diabetic patients,
non-diabetic individuals with IGT and sedentary adults after exercise training of different
intensity, different duration and different frequency an increase of insulin sensitivity was
found.
However, despite the vast knowledge concerning beneficial effects physical activity for the
prevention of T2DM (and many other chronic metabolic disorders) to date wide ranging
strategies have not been realized satisfactory. Regardless of age, ethnicity, sex or health
status the lack of time is the primary reason for the failure to exercise on a regular basis
(or is stated as primary reason). Therefore the investigators aimed at investigating whether
a controlled endurance/resistance training twice a week over 6 month might be beneficial for
healthy, non obese, first degree relatives with T2DM. Therefore the investigators measure
parameters associated with the prevention of T2DM like insulin sensitivity, flux through
fATPase and fCK, intramyocellular and hepatocellular lipids.
Clinical Details
Official title: Effects of Six Months of Moderate Resistance- Versus Endurance-Training on Muscle ATP Synthesis in First-Degree Relatives of Patients With Type 2 Diabetes
Study design: Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Primary outcome: Insulin Sensitivity
Secondary outcome: incremental test power, oxygen uptake (VO2 in ml.kg-1.min-1), "aerobic threshold" (RCP= respiratory compensation point)ATP-Synthesis liver lipid content skeletal muscle lipid content
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- First degree relatives of type 2 diabetic patients
- Age: 18-50 years
- BMI <30 kg/m2 (due to limited MR diameter)
- Normal routine lab tests (blood cell count, kidney, liver, pancreas, thyroid and
neuromuscular function)
- Availability within the local area throughout the study
- Ability to understand and sign the consent forms
Exclusion Criteria:
- Current smoking
- Present drug treatment
- Regular exercise training
- Contraindications for MRS studies: claustrophobia and metalliferous implants
- Pregnancy
- HIV or Hepatitis
- Acute disease 2 weeks previous to the examination
- Heart disease
- Hypertension (RR>140/95)
- Liver disease
- Kidney disease
- Pulmonary disease
- Thyroid disease
Locations and Contacts
Landsteiner Institute, Vienna 1140, Austria
Additional Information
Starting date: February 2006
Last updated: June 15, 2010
|