DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension

Information source: University of Zurich
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pulmonary Hypertension; Breathing-Related Sleep Disorder

Intervention: acetazolamide (Drug); Supplemental oxygen (Other); Non-invasive ventilation (Procedure); Room air (Other); Placebo tablet (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: University of Zurich

Official(s) and/or principal investigator(s):
01 Studienregister MasterAdmins, Study Director, Affiliation: UniversitaetsSpital Zuerich

Summary

The purpose of this study is to study the differential short-term effect of nocturnal oxygen, acetazolamide tablets and nocturnal non-invasive positive pressure ventilation on symptoms, exercise capacity and nocturnal breathing disturbances in subjects with pulmonary hypertension and sleep related breathing disorders

- Trial with medicinal product

Clinical Details

Official title: Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension (CSRPH)

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome:

exercise capacity

Quality of Life

Secondary outcome:

sleep related breathing disorders

hemodynamics measured by echocardiography

venous blood analysis

Nocturnal oxygen desaturation

arterial blood analysis

Vigilance

Eligibility

Minimum age: 20 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion criteria:

- percapillary pulmonary hypertension diagnosed by right heart catheterisation --

stable therapy and clinical condition for at least 4 weeks

- sleep disordered breathing with apnea/hypopnea index > 10 events/h and/or median

nocturnal oxygen saturation <90% Exclusion criteria:

- Pregnancy

- severe daytime hypoxemia (PaO2 < 7. 2 kPA)

- patients with predominantly obstructive sleep apnea.

Locations and Contacts

Respiratory Clinic, University Hospital of Zurich, Zurich 8091, Switzerland
Additional Information

Related publications:

Ulrich S, Fischler M, Speich R, Bloch KE. Sleep-related breathing disorders in patients with pulmonary hypertension. Chest. 2008 Jun;133(6):1375-80. doi: 10.1378/chest.07-3035. Epub 2008 Mar 13.

Starting date: November 2010
Last updated: December 11, 2012

Page last updated: August 20, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017