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Promethazine vs. Lorazepam for Treatment of Vertigo

Information source: Shahid Beheshti Medical University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Peripheral Vertigo.

Intervention: Promethazine (Drug); Lorazepam (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: Shahid Beheshti Medical University


This study was a prospective, randomized, double-blind, parallel group clinical trial designed to compare the efficacy of intravenous (IV) promethazine and lorazepam for the treatment of peripheral vertigo in Emergency Department setting.

Clinical Details

Official title: Promethazine vs. Lorazepam for Treatment of Vertigo in the Emergency Department: A Randomized Clinical Trial

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Mean change in vertigo intensity.

Secondary outcome: Efficacy and Safety outcome measures (nausea change-second dose-adverse events).


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Aged 18 years or older

- Background history of positional vertigo

Exclusion Criteria:

- Unable to provide informed consent

- Pregnant or possibly pregnant

- Known allergy to study medications

- Use of antiemetic agents in the previous 24 hours

- Evidence of drug-induced vertigo or orthostatic hypotension

- Central pathologies/central origin for vertigo

Locations and Contacts

Department of Neurology, Emam Hossein Hospital, Tehran, Nezam Abad 17666-33815, Iran, Islamic Republic of
Additional Information

Starting date: April 2013
Last updated: June 13, 2013

Page last updated: August 23, 2015

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