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Imaging of Atherosclerosis With 68Ga-MSA

Information source: Korea University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Atherosclerosis; Noninvasive Imaging of Atherosclerosis

Phase: N/A

Status: Completed

Sponsored by: Korea University


Despite of intensive efforts, no specific ath¬erosclerosis-targeting agent labeled with positron emitter is not yet available. Fortunately, some scientists made the major advance in the field of clinical atherosclerosis molecular imaging by the metabolic PET reporter agent 18F(fluorine-18)-FDG(Fludeoxyglucose) applied to noninvasively image plaque macrophages in carotid arteries. However, coronary and cerebral arterial segments remain uninterpretable due to metabolic property of 18F-FDG. Applying the character of the terminal mannose residues of MSA binding with the mannose receptors of macrophages in atherosclerosis, we investigate whether 68Ga-MSA can be a novel agent for non-invasive molecular imaging of atherosclerotic lesion in PET.

Clinical Details

Official title: Identification of Vascular Inflammatory Image Using a 68Ga-MSA(Gallium-68 Neomannosyl Human Serum Albumin) in Patients With Atherosclerotic Lesions

Study design: Observational Model: Case Control, Time Perspective: Prospective

Primary outcome: comparison of SUV(standard uptake unit) at atherosclerotic plaque of aorta and carotid arteries among 3 groups

Secondary outcome: side effect of PET imaging with 68Ga-MSA


Minimum age: N/A. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- acute coronary syndrome(acute myocardial infarction, unstable angina)

- chronic stable angina

- control without coronary artery disease

Exclusion Criteria:

- pregnancy, allergy to albumin, chronic inflammatory disease

Locations and Contacts

Korea University Guro Hospital, Seoul 152-703, Korea, Republic of
Additional Information

Starting date: August 2012
Last updated: August 23, 2013

Page last updated: August 23, 2015

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