Influence of Salbutamol on Emotional and Cognitive Functions in Healthy Subjects
Information source: University of Basel
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Memory Functions
Intervention: Salbutamol (Drug); Placebo (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: Prof. Dominique de Quervain, MD Official(s) and/or principal investigator(s): Dominique de Quervain, Prof. MD, Study Director, Affiliation: University of Basel
Summary
Aim is to investigate the effect of beta2 adrenergic stimulant salbutamol on emotional and
cognitive functions in healthy humans.
Clinical Details
Official title: Influence of Salbutamol on Emotional and Cognitive Functions in Healthy Subjects
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
Primary outcome: Change of emotional memory functions under SalbutamolChange of episodic memory functions under Salbutamol
Secondary outcome: Change of emotional state under salbutamolchange of attention functions under salbutamol
Eligibility
Minimum age: 18 Years.
Maximum age: 40 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
Healthy, male and female, aged between 18 and 40, BMI be-tween 19 and 27 kg/m2,
normotensive (BP between 90/60 mmHg and 140/90 mmHg), native or fluent German-speaking,
caucasian (European ancestry), able and willing to give written informed consent and
comply with the requirements of the study protocol, willing to donate saliva sample for
DNA-analysis -
Exclusion Criteria:
Acute or chronic psychiatric or somatic disorder, tachycardia at rest (> 100 bpm), known
hypersensitivity to salbutamol, pathological ECG, pregnancy, breast-feeding, long-term
medication within last 3 months (oral contraceptives are disregarded) smoking (>3
cigarettes per day), concurrent participation in another study, participation in one of
our previous studies using the same memory tests, inability to read and understand the
participant's information. -
Locations and Contacts
University of Basel, Division of Cognitive neuroscience, Basel 4055, Switzerland
Additional Information
Starting date: October 2013
Last updated: December 15, 2014
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