Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes
Information source: Weill Medical College of Cornell University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy
Intervention: Thiopental (Drug); Propofol (Drug)
Phase: Phase 4
Status: Active, not recruiting
Sponsored by: Weill Medical College of Cornell University Official(s) and/or principal investigator(s): Kane Pryor, M.D., Principal Investigator, Affiliation: Weill Medical College of Cornell University
Summary
This study involves 90 healthy volunteers aged between 18 and 50 recruited from the general
community. It involves doing a set of simple memory tests while inside a fMRI machine. The
subject is given a very low dose of an anesthetic drug intravenously while in the scanner.
The subject then sees a sequence of pictures on a screen, and presses a button if they
remember seeing the picture before. While this is happening, the scanner will be capturing
images that tell us what parts of the brain are active. Hypothesis: patterns of hippocampal
and amygdala activation during the encoding and retrieval of memory,as measured by fMRI,
will be altered by intravenous anesthetics such that suppression of hippocampal and amygdala
activities will be dissociable. This dissociation pattern will be different between the
drugs propofol and thiopental
Clinical Details
Official title: Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)
Primary outcome: Performance on memory tasks
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- age b/w 18 and 50
- right-handed
- minimum of high school education
- fluent in English
- normal vocabulary
Exclusion Criteria:
- any significant medical/psychiatric comorbidity
- deficit in vision or hearing that would impede the study
- allergies to any of the study drugs, to soybeans, or eggs.
- history of head trauma
- family history of major psychiatric illness
- body mass index > 30 kg/m2
- claustrophobia
- prior exposure to IAPS pictures
- pregnancy
- permanent metal objects anywhere in the body
- a personal/family history of any porphyria
Locations and Contacts
Weill Cornell Medical College, New York, New York 10065, United States
Additional Information
Starting date: March 2007
Last updated: January 28, 2015
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