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Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

Information source: Weill Medical College of Cornell University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy

Intervention: Thiopental (Drug); Propofol (Drug)

Phase: Phase 4

Status: Active, not recruiting

Sponsored by: Weill Medical College of Cornell University

Official(s) and/or principal investigator(s):
Kane Pryor, M.D., Principal Investigator, Affiliation: Weill Medical College of Cornell University

Summary

This study involves 90 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine. The subject is given a very low dose of an anesthetic drug intravenously while in the scanner. The subject then sees a sequence of pictures on a screen, and presses a button if they remember seeing the picture before. While this is happening, the scanner will be capturing images that tell us what parts of the brain are active. Hypothesis: patterns of hippocampal and amygdala activation during the encoding and retrieval of memory,as measured by fMRI, will be altered by intravenous anesthetics such that suppression of hippocampal and amygdala activities will be dissociable. This dissociation pattern will be different between the drugs propofol and thiopental

Clinical Details

Official title: Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)

Primary outcome: Performance on memory tasks

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- age b/w 18 and 50

- right-handed

- minimum of high school education

- fluent in English

- normal vocabulary

Exclusion Criteria:

- any significant medical/psychiatric comorbidity

- deficit in vision or hearing that would impede the study

- allergies to any of the study drugs, to soybeans, or eggs.

- history of head trauma

- family history of major psychiatric illness

- body mass index > 30 kg/m2

- claustrophobia

- prior exposure to IAPS pictures

- pregnancy

- permanent metal objects anywhere in the body

- a personal/family history of any porphyria

Locations and Contacts

Weill Cornell Medical College, New York, New York 10065, United States
Additional Information

Starting date: March 2007
Last updated: January 28, 2015

Page last updated: August 23, 2015

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