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Recovery of Bupivacaine or Bupivacaine-Lidocaine Spinal Anesthesia and Infiltration Anesthesia in Herniorrhaphy

Information source: Diskapi Teaching and Research Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Anesthesia; Inguinal Hernia

Intervention: spinal anesthesia (Procedure); spinal anesthesia (Procedure); infiltration anesthesia (Procedure)

Phase: Phase 4

Status: Completed

Sponsored by: Diskapi Teaching and Research Hospital

Official(s) and/or principal investigator(s):
Dilek Yazicioglu, Principal Investigator


The purpose of this study is the investigation of whether adding lidocaine to hyperbaric bupivacaine could decrease the duration of bupivacaine spinal block and provide shorter recovery and discharge times than local infiltration anesthesia in outpatient herniorrhaphy procedures.

Clinical Details

Official title: A Comparison of the Recovery Profiles of Bupivacaine or Bupivacaine Mixed With Lidocaine Spinal Anesthesia and Local Infiltration Anesthesia for Outpatient Herniorrhaphy

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)

Primary outcome: Duration of spinal block

Secondary outcome: Discharge time

Detailed description: Consecutive 93 patients undergoing inguinal herniorrhaphy will be recruited with a prospective protocol. Spinal anesthesia will be commenced in Group BLS with 2 ml hyperbaric bupivacaine (10 mg) + 0. 6 ml 1 % lidocaine (6 mg), in Group BS, hyperbaric bupivacaine (10 mg) + saline in the same volume and Group LIA will have anesthesia with bupivacaine and lidocaine for step by step local anesthetic infiltration. Sensorial block will be measured with pinprick test, motor block will be tested with Bromage scale. Heart rate, blood pressure and peripheral oxygen saturation will be measured every 5 minutes. Time of subarachnoid injection, onset of sensorial block (block at L1 dermatome), time to block T10 dermatome, maximum block level, time to maximum block and time to two segment regression, T10 regression , LI regression and S1 regression of the block will be recorded in group BLS and BS. The onset and resolution of the sensorial and motor block will be assessed by anesthetists blinded to group allocation. PACU stay and discharge times and VAS pain scores will be recorded in all patients. Patients also will be investigated for adverse events (hypotension, bradycardia, nausea,PDPH, TNS, urinary retention)and satisfaction regarding the anesthetic method.


Minimum age: 19 Years. Maximum age: 80 Years. Gender(s): Both.


Inclusion Criteria:

- Patients having inguinal hernia

- Not hypersensitive to study drugs

- ASA classification I-III

Exclusion Criteria:

- ASA classification IV-V

- Contraindications for spinal anesthesia

Locations and Contacts

Diskapi Yildirim Beyazit Training and Research Hospital, Ankara 06610, Turkey
Additional Information

Related publications:

Lee SJ, Bai SJ, Lee JS, Kim WO, Shin YS, Lee KY. The duration of intrathecal bupivacaine mixed with lidocaine. Anesth Analg. 2008 Sep;107(3):824-7. doi: 10.1213/ane.0b013e3181806149.

Starting date: March 2012
Last updated: April 21, 2015

Page last updated: August 23, 2015

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