Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach

Condition(s) targeted: Hypoalbuminemia; Adult ICU Patient; Stewart Approach for Acid Base Disorders; Human Albumin Perfusion

Intervention: stewart approach (Other)

Phase: N/A

Status: Active, not recruiting

Sponsored by: University Hospital, Clermont-Ferrand

Official(s) and/or principal investigator(s):
Julien PASCAL, Principal Investigator, Affiliation: University Hospital, Clermont-Ferrand

The primary purpose was to describe the acid base balance of ICU patients with severe hypoalbuminemia using Stewart's approach for acid base disorders, before and after an human albumin perfusion.

Official title: Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach

Study design: Time Perspective: Cross-Sectional

Primary outcome: changes in pH and independent pH determinants using Stewart approach

Secondary outcome:

changes in neurologic parameters

changes in hemodynamic parameters

changes in respiratory parameters

Detailed description: Prospective study, for ICU patient with severe hypoalbuminemia < 20g/L, determining biological parameters from Stewart approach for acid base disorders (pH, SIDe, SIDa, SIG, Atot, PaCO2) before, and at 1hour, 2hours and 24 hours after a 200mL 20% human albumin perfusion (the consensus conference ANAES of 1995 recommands to correct hypoalbuminemia below 20g/L). Clinical parameters (respiratory, haemodynamic, neurologic) were also collected at the same times.

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- serum albuminemia < 20g/L

- adult ICU patient

- Arterial line

Exclusion Criteria:

- albumin allergy

- pregnancy

- congestive heart failure

CHU de Clermont-Ferrand, Clermont-Ferrand 63003, France

Starting date: October 2013
Last updated: November 7, 2014