Intravenous Remifentanil Plus Morphine or Morphine Alone for Postthoracotomy Pain

Condition(s) targeted: Pain

Intervention: Remifentanil+morphine (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Cukurova University

Official(s) and/or principal investigator(s):
Mediha Turktan, Assist Prof, Study Director, Affiliation: Cukurova University, Department of Anaesthesiology

Background; Post-thoracotomy pain remains a major problem. This double-blind, randomized study tested the effects of coadministration of patient controlled remifentanil+morphine combination on postthoracotomy pain, analgesic consumption and side effects compared with morphine PCA alone

Official title: COADMINISTRATION OF INTRAVENOUS REMIFENTANIL AND MORPHINE FOR POSTTHORACOTOMY PAIN; COMPARISON WITH IV MORPHINE ALONE

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: COADMINISTRATION OF INTRAVENOUS REMIFENTANIL AND MORPHINE FOR POSTTHORACOTOMY PAIN; COMPARISON WITH IV MORPHINE ALONE

Detailed description: Methods; Sixty patients were allocated randomly to receive an intravenous patient-controlled analgesia with morphine alone (M), or morphine plus remifentanil (MR), in a double-blind manner. Postoperatively patients were allowed to use bolus doses of morphine (0. 2 mg kg-1) or morphine (0. 2 mg kg-1) plus remifentanil (0. 2 µg kg-1) mixture every 10 min without a background infusion. Pain, discomfort, sedation scores, total and bolus patient-controlled morphine consumption, rescue analgesic requirement and side-effects were recorded for up to 24 h after the start of patient-controlled analgesia.

Minimum age: 18 Years. Maximum age: 59 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- 60 ASA physical status I-III patients, between the ages of 18 and 59 years, scheduled

for elective thoracotomy surgery with general anaesthesia were included in this study Exclusion Criteria:

- severe hepatorenal disease history, sensitivity or contraindication to morphine and

remifentanil, chronic pain (defined as regular use of opioid analgesics for > 3 months), drug or alcohol abuse and contraindication to administration of PCA

Hakkı Unlugenc, Adana 01330, Turkey

Starting date: May 2011
Last updated: April 10, 2013