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Ethyl Eicosapentanoic Acid (Ethyl-EPA) for Treating Major Depression

Information source: National Center for Complementary and Integrative Health (NCCIH)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Depressive Disorder; Depression

Intervention: Ethyl-eicosapentanoic acid (ethyl-EPA) (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: National Center for Complementary and Integrative Health (NCCIH)

Official(s) and/or principal investigator(s):
David Mischoulon, MD, PhD, Principal Investigator, Affiliation: Massachusetts General Hospital

Summary

The purpose of this study is to examine the effectiveness of ethyl-eicosapentanoic acid (ethyl-EPA), an omega-3 fatty acid, in treating depression.

Clinical Details

Official title: A Double-Blind, Placebo-Controlled Study of Ethyl Eicosapentanoic Acid (Ethyl-EPA) in Major Depressive Disorder

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Primary outcome: Alleviation of depressive symptoms

Detailed description: Evidence suggests that omega-3 fatty acids may help reduce symptoms of depression. This study will determine whether ethyl-EPA, an omega-3 fatty acid, can be used safely and effectively to treat major depression. Participants will be randomly assigned to receive either ethyl EPA-containing pills or placebo daily for 8 weeks. Each week, participants will be asked to complete questionnaires which will be used to assess the severity of their depression.

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Major depressive disorder

Exclusion Criteria:

- Serious comorbid psychiatric disorder

- Unstable medical illness

- Prior use of any omega-3 fatty acid product

Locations and Contacts

Massachusetts General Hospital, Boston, Massachusetts 02114, United States
Additional Information

Starting date: September 2001
Last updated: January 15, 2008

Page last updated: August 23, 2015

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