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Prochlorperazine vs Imitrex for Acute Migraine in the Emergency Department

Information source: United States Naval Medical Center, Portsmouth
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Acute Migraine Headache

Intervention: prochlorperazine and benadryl IV (Drug); Imitrex SubQ, saline IV (Drug)

Phase: N/A

Status: Completed

Sponsored by: United States Naval Medical Center, Portsmouth

Official(s) and/or principal investigator(s):
Frank Gutierrez, MD, Principal Investigator, Affiliation: US Navy


ED patients with acute migraine will be randomized to either prochlorperazine and Bendaryl OR imitrex. VAS for pain will be monitored, along with side effects. Primary outcome measure is improvement in pain scales between the groups.

Clinical Details

Official title: Prochlorperazine vs Imitrex for Acute Migraine in the Emergency Department

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Difference in pain measured by VAS

Secondary outcome: Degree of sedation, nausea, akathisia


Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.


Inclusion Criteria:

- Acute migraine headache

Exclusion Criteria:

- Pregnant

- Hypertension

- Chest pain

- < 18

- Allergy to any of the meds

Locations and Contacts

Naval Medical Center Portsmouth, Portsmouth, Virginia 23708, United States
Additional Information

Starting date: February 2007
Last updated: December 13, 2007

Page last updated: August 23, 2015

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