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Effect of Amlodipine Monotherapy or Combined With Terazosin on Lower Urinary Tract Symptoms and Hypertension

Information source: Anhui Medical University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Lower Urinary Tract Symptoms; Hypertension

Intervention: amlodipine (Drug); terazosin (Drug); amlodipine plus terazosin (Drug)

Phase: N/A

Status: Completed

Sponsored by: Anhui Medical University

Official(s) and/or principal investigator(s):
Ping Liu, PhD, Study Director, Affiliation: Biomedical Institute of Anhui Medical University


The aim of this study was to investigate the efficacy and safety of low dose amlodipine alone, or combined with low dose terazosin in male patients with both lower urinary tract symptoms and hypertension.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: The primary efficacy outcomes were reductions in blood pressure and International Prostate Symptoms Score (IPSS) and sub-scores.


Minimum age: 50 Years. Maximum age: N/A. Gender(s): Male.


Inclusion Criteria: 1. Men 50 years or older 2. with LUTS [defined as International Prostate Symptom Score (IPSS) >= 10]. 3. Stage 1 or 2 essential hypertension (SBP >= 140 mm Hg and < 180 mm Hg and/or DBP >= 90 mm Hg and < 110 mm Hg) Exclusion Criteria: 1. A history of postural hypotension 2. Secondary hypertension 3. Prostate cancer 4. Prostate surgery or other intervention 5. Use of any agents to influence the LUTS symptoms in the last 4 weeks 6. Other severe diseases

Locations and Contacts

Biomedicine Inistitute of Anhui Medical University, Hefei, Anhui 230032, China
Additional Information

Starting date: July 2006
Last updated: August 7, 2008

Page last updated: August 23, 2015

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