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Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine

Information source: University of Lausanne Hospitals
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Pain

Intervention: Lidocaine, (Drug); Ketamine (Drug); association ketamine-lidocaine (Drug); Placebo (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Lausanne Hospitals

Official(s) and/or principal investigator(s):
Christian Kern, Study Director, Affiliation: University of Lausanne Hospitals


The aim of the present study is to evaluate the analgesic benefit of intravenous lidocaine and ketamine in the perioperative period of abdominal surgery.

Clinical Details

Official title: Analgesic Efficacy of Intravenous Perfusion of Lidocaine, Ketamine or a Combination After Laparotomy in a Placebo-controlled, Randomized, Double-blind Prospective Study

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Cumulative morphine consumption

Secondary outcome:

Pain scores

Mechanical hyperalgesia

Occurrence of side effects

Detailed description: Optimal postoperative pain management facilitates rehabilitation immediately after abdominal surgery. Multiple studies have demonstrated that successful postoperative analgesia also reduces perioperative complications and improves patient comfort, thereby providing many benefits for the patient. In acute postoperative pain management intravenous lidocaine and/or ketamine have been advocated because of their morphine-sparing effect.


Minimum age: 20 Years. Maximum age: 75 Years. Gender(s): Both.


Inclusion Criteria:

- abdominal surgery by laparotomy

Exclusion Criteria:

- laparoscopy

- history of chronic pain

- opioid self-administration

- psychiatric disorders

- difficulties with communication

- renal or hepatic dysfunction

- ASA physical status > 3

Locations and Contacts

University Hospital Center and University, Lausanne, Vaud CH-1011, Switzerland
Additional Information

Starting date: December 2005
Last updated: September 21, 2011

Page last updated: August 23, 2015

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