Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients
Information source: Mashhad University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Graves Disease
Intervention: Methimazole (Drug); Methimazole (Drug); Methimazole (Drug)
Phase: N/A
Status: Completed
Sponsored by: Mashhad University of Medical Sciences Official(s) and/or principal investigator(s): rasoul zakavi, associate professor, Principal Investigator, Affiliation: Mashhad University of Medical Sciences
Summary
Iodine therapy is the best treatment for graves disease. Most patients receive methimozale
prior to radio-iodine treatment. This may decrease treatment response to iodine therapy.
Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and
others prefer longer off - methimazole period which bothers most patients. This study aimed
to evaluate optimum time for methimazole discontinuation in graves disease.
Clinical Details
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: thyroid function tests over one year after radioiodine therapy
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- age 18-65
- graves disease(TSH<0. 1 &increased FT4 & positive TSI
- one or more bartlena criteria for radio-iodine therapy
- 24 hour RAIU>25%
- euthyroidism after methimazole treatment
Exclusion Criteria:
- pregnancy or lactation
- moderate or severe graves ophthalmopathy
- CHF or coronary heart disease
- palpable thyroid nodule
- lithium or amiodarone or lugol or ipodate treatment
- recent imaging with contrast agent
- very large goiter(more than 150 gram)
Locations and Contacts
Mashad University of Medical Sciences, Mashad, Khorasan Razavi 91766, Iran, Islamic Republic of
Additional Information
Starting date: February 2010
Last updated: March 20, 2012
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