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Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients

Information source: Mashhad University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Graves Disease

Intervention: Methimazole (Drug); Methimazole (Drug); Methimazole (Drug)

Phase: N/A

Status: Completed

Sponsored by: Mashhad University of Medical Sciences

Official(s) and/or principal investigator(s):
rasoul zakavi, associate professor, Principal Investigator, Affiliation: Mashhad University of Medical Sciences


Iodine therapy is the best treatment for graves disease. Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy. Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and

others prefer longer off - methimazole period which bothers most patients. This study aimed

to evaluate optimum time for methimazole discontinuation in graves disease.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: thyroid function tests over one year after radioiodine therapy


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- age 18-65

- graves disease(TSH<0. 1 &increased FT4 & positive TSI

- one or more bartlena criteria for radio-iodine therapy

- 24 hour RAIU>25%

- euthyroidism after methimazole treatment

Exclusion Criteria:

- pregnancy or lactation

- moderate or severe graves ophthalmopathy

- CHF or coronary heart disease

- palpable thyroid nodule

- lithium or amiodarone or lugol or ipodate treatment

- recent imaging with contrast agent

- very large goiter(more than 150 gram)

Locations and Contacts

Mashad University of Medical Sciences, Mashad, Khorasan Razavi 91766, Iran, Islamic Republic of
Additional Information

Starting date: February 2010
Last updated: March 20, 2012

Page last updated: August 23, 2015

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